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KV11.1, NaV1.5, and CaV1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity

Department of Organic Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland
Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Toruń, Poland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 8099;
Received: 5 October 2020 / Revised: 24 October 2020 / Accepted: 27 October 2020 / Published: 30 October 2020
(This article belongs to the Special Issue Drug Transporters)
Safety assessment of pharmaceuticals is a rapidly developing area of pharmacy and medicine. The new advanced guidelines for testing the toxicity of compounds require specialized tools that provide information on the tested drug in a quick and reliable way. Ion channels represent the third-largest target. As mentioned in the literature, ion channels are an indispensable part of the heart’s work. In this paper the most important information concerning the guidelines for cardiotoxicity testing and the way the tests are conducted has been collected. Attention has been focused on the role of selected ion channels in this process. View Full-Text
Keywords: antitarget; drug cardiotoxicity; ion transporter proteins antitarget; drug cardiotoxicity; ion transporter proteins
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Kowalska, M.; Nowaczyk, J.; Nowaczyk, A. KV11.1, NaV1.5, and CaV1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity. Int. J. Mol. Sci. 2020, 21, 8099.

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