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Article

Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study

1
Chair of Medical Biology, Laboratory of Metabolomic Studies, Department of Structural Biology, Faculty of Medicine Department of Biomedical Sciences, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland
2
Masdiag Diagnostic Laboratory, Żeromskiego 33, 01-882 Warszawa, Poland
3
Department of Diabetology and Internal Diseases, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7811; https://doi.org/10.3390/ijms21217811
Received: 18 September 2020 / Revised: 16 October 2020 / Accepted: 19 October 2020 / Published: 22 October 2020
(This article belongs to the Special Issue Pathogenesis of Pregnancy-Related Complications 2.0)
In the reported study we applied the targeted metabolomic profiling employing high pressure liquid chromatography coupled with triple quadrupole tandem mass spectrometry (HPLC–MS/MS) to understand the pathophysiology of gestational diabetes mellitus (GDM), early identification of women who are at risk of developing GDM, and the differences in recovery postpartum between these women and normoglycemic women. We profiled the peripheral blood from patients during the second trimester of pregnancy and three months, and one year postpartum. In the GDM group Arg, Gln, His, Met, Phe and Ser were downregulated with statistical significance in comparison to normoglycemic (NGT) women. From the analysis of the association of all amino acid profiles of GDM and NGT women, several statistical models predicting diabetic status were formulated and compared with the literature, with the arginine-based model as the most promising of the screened ones (area under the curve (AUC) = 0.749). Our research results have shed light on the critical role of arginine in the development of GDM and may help in precisely distinguishing between GDM and NGT and earlier detection of GDM but also in predicting women with the increased type 2 diabetes mellitus (T2DM) risk. View Full-Text
Keywords: GDM; arginine; follow-up studies; T2DM risk GDM; arginine; follow-up studies; T2DM risk
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MDPI and ACS Style

Burzynska-Pedziwiatr, I.; Jankowski, A.; Kowalski, K.; Sendys, P.; Zieleniak, A.; Cypryk, K.; Zurawska-Klis, M.; Wozniak, L.A.; Bukowiecka-Matusiak, M. Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study. Int. J. Mol. Sci. 2020, 21, 7811. https://doi.org/10.3390/ijms21217811

AMA Style

Burzynska-Pedziwiatr I, Jankowski A, Kowalski K, Sendys P, Zieleniak A, Cypryk K, Zurawska-Klis M, Wozniak LA, Bukowiecka-Matusiak M. Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study. International Journal of Molecular Sciences. 2020; 21(21):7811. https://doi.org/10.3390/ijms21217811

Chicago/Turabian Style

Burzynska-Pedziwiatr, Izabela, Adrian Jankowski, Konrad Kowalski, Przemyslaw Sendys, Andrzej Zieleniak, Katarzyna Cypryk, Monika Zurawska-Klis, Lucyna A. Wozniak, and Malgorzata Bukowiecka-Matusiak. 2020. "Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study" International Journal of Molecular Sciences 21, no. 21: 7811. https://doi.org/10.3390/ijms21217811

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