Next Article in Journal
In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria
Next Article in Special Issue
Sex Specific Expression of Interleukin 7, 8 and 15 in Placentas of Women with Gestational Diabetes
Previous Article in Journal
The Roles of CCN1/CYR61 in Pulmonary Diseases
Previous Article in Special Issue
Gestational Diabetes Type 2: Variation in High-Density Lipoproteins Composition and Function

Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study

Chair of Medical Biology, Laboratory of Metabolomic Studies, Department of Structural Biology, Faculty of Medicine Department of Biomedical Sciences, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland
Masdiag Diagnostic Laboratory, Żeromskiego 33, 01-882 Warszawa, Poland
Department of Diabetology and Internal Diseases, Medical University of Lodz, Pomorska 251, 92-213 Lodz, Poland
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7811;
Received: 18 September 2020 / Revised: 16 October 2020 / Accepted: 19 October 2020 / Published: 22 October 2020
(This article belongs to the Special Issue Pathogenesis of Pregnancy-Related Complications 2.0)
In the reported study we applied the targeted metabolomic profiling employing high pressure liquid chromatography coupled with triple quadrupole tandem mass spectrometry (HPLC–MS/MS) to understand the pathophysiology of gestational diabetes mellitus (GDM), early identification of women who are at risk of developing GDM, and the differences in recovery postpartum between these women and normoglycemic women. We profiled the peripheral blood from patients during the second trimester of pregnancy and three months, and one year postpartum. In the GDM group Arg, Gln, His, Met, Phe and Ser were downregulated with statistical significance in comparison to normoglycemic (NGT) women. From the analysis of the association of all amino acid profiles of GDM and NGT women, several statistical models predicting diabetic status were formulated and compared with the literature, with the arginine-based model as the most promising of the screened ones (area under the curve (AUC) = 0.749). Our research results have shed light on the critical role of arginine in the development of GDM and may help in precisely distinguishing between GDM and NGT and earlier detection of GDM but also in predicting women with the increased type 2 diabetes mellitus (T2DM) risk. View Full-Text
Keywords: GDM; arginine; follow-up studies; T2DM risk GDM; arginine; follow-up studies; T2DM risk
Show Figures

Figure 1

MDPI and ACS Style

Burzynska-Pedziwiatr, I.; Jankowski, A.; Kowalski, K.; Sendys, P.; Zieleniak, A.; Cypryk, K.; Zurawska-Klis, M.; Wozniak, L.A.; Bukowiecka-Matusiak, M. Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study. Int. J. Mol. Sci. 2020, 21, 7811.

AMA Style

Burzynska-Pedziwiatr I, Jankowski A, Kowalski K, Sendys P, Zieleniak A, Cypryk K, Zurawska-Klis M, Wozniak LA, Bukowiecka-Matusiak M. Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study. International Journal of Molecular Sciences. 2020; 21(21):7811.

Chicago/Turabian Style

Burzynska-Pedziwiatr, Izabela, Adrian Jankowski, Konrad Kowalski, Przemyslaw Sendys, Andrzej Zieleniak, Katarzyna Cypryk, Monika Zurawska-Klis, Lucyna A. Wozniak, and Malgorzata Bukowiecka-Matusiak. 2020. "Associations of Arginine with Gestational Diabetes Mellitus in a Follow-Up Study" International Journal of Molecular Sciences 21, no. 21: 7811.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop