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Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases

Centre for Cardiovascular Investigations, Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada
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Int. J. Mol. Sci. 2020, 21(2), 542; https://doi.org/10.3390/ijms21020542
Received: 17 December 2019 / Revised: 6 January 2020 / Accepted: 12 January 2020 / Published: 15 January 2020
(This article belongs to the Section Molecular Biology)
Sarcomere assembly and maintenance are essential physiological processes required for cardiac and skeletal muscle function and organism mobility. Over decades of research, components of the sarcomere and factors involved in the formation and maintenance of this contractile unit have been identified. Although we have a general understanding of sarcomere assembly and maintenance, much less is known about the development of the thin filaments and associated factors within the sarcomere. In the last decade, advancements in medical intervention and genome sequencing have uncovered patients with novel mutations in sarcomere thin filaments. Pairing this sequencing with reverse genetics and the ability to generate patient avatars in model organisms has begun to deepen our understanding of sarcomere thin filament development. In this review, we provide a summary of recent findings regarding sarcomere assembly, maintenance, and disease with respect to thin filaments, building on the previous knowledge in the field. We highlight debated and unknown areas within these processes to clearly define open research questions. View Full-Text
Keywords: sarcomere assembly; sarcomere maintenance; sarcomere thin filaments; thin filament assembly; thin filament maintenance; thin filament turnover; actin turnover; chaperone; sarcomere; myopathy sarcomere assembly; sarcomere maintenance; sarcomere thin filaments; thin filament assembly; thin filament maintenance; thin filament turnover; actin turnover; chaperone; sarcomere; myopathy
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MDPI and ACS Style

Prill, K.; Dawson, J.F. Assembly and Maintenance of Sarcomere Thin Filaments and Associated Diseases. Int. J. Mol. Sci. 2020, 21, 542.

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