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Open AccessArticle

Site-Specific Expression Pattern of PIWI-Interacting RNA in Skin and Oral Mucosal Wound Healing

by Lin Chen 1,2,†, Zujian Chen 2,†, Alyne Simões 1,3, Xinming Wu 2, Yang Dai 4,5, Luisa A. DiPietro 1,2,5,* and Xiaofeng Zhou 1,2,5,6,*
1
Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
2
Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
3
Oral Biology Laboratory, Department of Biomaterials and Oral Biology, School of Dentistry, University of São Paulo, São Paulo, SP 05508-000, Brazil
4
Department of Bioengineering, College of Engineering, University of Illinois at Chicago, Chicago, IL 60607, USA
5
Graduate College, University of Illinois at Chicago, Chicago, IL 60607, USA
6
UIC Cancer Center, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(2), 521; https://doi.org/10.3390/ijms21020521
Received: 26 November 2019 / Revised: 2 January 2020 / Accepted: 11 January 2020 / Published: 14 January 2020
(This article belongs to the Section Molecular Genetics and Genomics)
The oral mucosa exhibits exceptional healing capability when compared to skin. Recent studies suggest that intrinsic differences in coding genes and regulatory small non-coding RNA (sncRNA) genes (e.g., microRNAs) may underlie the exceptional healing that occurs in the oral mucosa. Here, we investigate the role of a novel class of sncRNA—Piwi-interacting RNA (piRNA)—in the tissue-specific differential response to injury. An abundance of piRNAs was detected in both skin and oral mucosal epithelium during wound healing. The expression of PIWI genes (the obligate binding partners of piRNAs) was also detected in skin and oral wound healing. This data suggested that PIWI-piRNA machinery may serve an unknown function in the highly orchestrated wound healing process. Furthermore, unique tissue-specific piRNA profiles were obtained in the skin and oral mucosal epithelium, and substantially more changes in piRNA expression were observed during skin wound healing than oral mucosal wound healing. Thus, we present the first clue suggesting a role of piRNA in wound healing, and provide the first site-specific piRNA profile of skin and oral mucosal wound healing. These results serve as a foundation for the future investigation of the functional contribution(s) of piRNA in wound repair and tissue regeneration. View Full-Text
Keywords: wound healing; piRNA; PIWI gene; oral mucosa; skin wound healing; piRNA; PIWI gene; oral mucosa; skin
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MDPI and ACS Style

Chen, L.; Chen, Z.; Simões, A.; Wu, X.; Dai, Y.; DiPietro, L.A.; Zhou, X. Site-Specific Expression Pattern of PIWI-Interacting RNA in Skin and Oral Mucosal Wound Healing. Int. J. Mol. Sci. 2020, 21, 521.

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