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Human Induced Pluripotent Stem Cells Derived from a Cardiac Somatic Source: Insights for an In-Vitro Cardiomyocyte Platform

1
Department of Biotechnology and Biosciences, Università degli Studi di Milano-Bicocca, Milano 20126, Italy
2
Fondazione Cardiocentro Ticino, Lugano 6900, Switzerland
3
Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano 6900, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 507; https://doi.org/10.3390/ijms21020507
Received: 18 December 2019 / Revised: 10 January 2020 / Accepted: 10 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue From hIPSCs to Adult Cells in a Dish: Promises and Pitfalls)
Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) has revolutionized the complex scientific field of disease modelling and personalized therapy. Cardiac differentiation of human iPSCs into cardiomyocytes (hiPSC-CMs) has been used in a wide range of healthy and disease models by deriving CMs from different somatic cells. Unfortunately, hiPSC-CMs have to be improved because existing protocols are not completely able to obtain mature CMs recapitulating physiological properties of human adult cardiac cells. Therefore, improvements and advances able to standardize differentiation conditions are needed. Lately, evidences of an epigenetic memory retained by the somatic cells used for deriving hiPSC-CMs has led to evaluation of different somatic sources in order to obtain more mature hiPSC-derived CMs. View Full-Text
Keywords: hiPSC-CMs; epigenetic memory; maturation; cell modelling; drug testing hiPSC-CMs; epigenetic memory; maturation; cell modelling; drug testing
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Lodrini, A.M.; Barile, L.; Rocchetti, M.; Altomare, C. Human Induced Pluripotent Stem Cells Derived from a Cardiac Somatic Source: Insights for an In-Vitro Cardiomyocyte Platform. Int. J. Mol. Sci. 2020, 21, 507.

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