Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Data Analysis
4.2. Association Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
SNP | Single Nucleotide Polymorphism |
BMI | Body Mass Index |
AIMs | Ancestry-Informative Markers |
WHO | World Health Organization |
AMA | Amerindian Ancestry |
PCA | Principal Component Analysis |
GRS | Genetic Risk Score |
References
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Ethnic Group | Sex (Number) | BMI | Prevalence (%) | |
---|---|---|---|---|
Mean (SD) | Overweight | Obesity | ||
NMM | Girls (n = 100) | 19.0 (4.6) | 17.0 | 29.0 |
Boys (n = 78) | 18.9 (4.1) | 20.5 | 28.2 | |
Yaquis | Girls (n = 51) | 17.3 (4.5) | 9.8 | 7.8 |
Boys (n = 72) | 17.3 (4.2) | 20.8 | 9.7 | |
Seris | Girls (n = 41) | 18.2 (3.3) | 14.6 | 17.1 |
Boys (n = 27) | 19.2 (5.6) | 14.8 | 25.9 | |
CMM, indigenous school | Girls (n = 531) | 17.2 (3.0) | 11.9 | 15.4 |
Boys (n = 480) | 17.2 (3.1) | 12.5 | 15.4 | |
CMM, regular school | Girls (n = 3761) | 17.6 (3.2) | 14.6 | 20.3 |
Boys (n = 3773) | 17.7 (3.2) | 16.4 | 19.3 |
Gene | Chr | SNP | AA | NMM/Yaquis (n = 301) | Seris (n = 68) | p | CM (n = 8545) | p | |
---|---|---|---|---|---|---|---|---|---|
β (SE) | p | β (SE) | β (SE) | ||||||
SEC16B | 1 | rs543874 | G | 0.21 (0.14) | 0.15 | −0.29 (0.25) | 0.24 | 0.10 (0.02) | 3.4 × 10−8 |
OLFM4 | 13 | rs12429545 | G | −0.20 (0.11) | 0.08 | 0.02 (0.25) | 0.94 | −0.07 (0.01) | 1.2 × 10−6 |
FTO | 16 | rs9939609 | A | 0.03 (0.13) | 0.79 | 0.34 (0.36) | 0.35 | 0.11 (0.02) | 2.4 × 10−6 |
MC4R | 18 | rs6567160 | C | −0.03 (0.20) | 0.87 | −0.24 (0.51) | 0.64 | 0.13 (0.03) | 4.5 × 10−5 |
GNPDA2 | 4 | rs13130484 | T | −0.08 (0.11) | 0.46 | 0.12 (0.18) | 0.53 | 0.06 (0.01) | 3.4 × 10−4 |
OLFM4 | 13 | rs9568856 | G | 0.14 (0.10) | 0.19 | 0.05 (0.23) | 0.82 | −0.05 (0.01) | 1.0 × 10−3 |
FAIM2 | 5 | rs7132908 | A | −0.24 (0.14) | 0.08 | 0.12 (0.37) | 0.75 | 0.06 (0.02) | 3.0 × 10−3 |
FAM120AOS | 12 | rs944990 | A | −0.08 (0.12) | 0.48 | 0.32 (0.25) | 0.21 | 0.05 (0.01) | 0.01 |
LMX1B | 9 | rs3829849 | A | 0.05 (0.13) | 0.69 | 0.02 (0.34) | 0.99 | 0.06 (0.02) | 0.02 |
HOXB5 | 9 | rs9299 | A | 0.02 (0.10) | 0.86 | −0.36 (0.21) | 0.10 | 0.03 (0.01) | 0.03 |
ADAM23 | 17 | rs13387838 | G | 0.01 (0.35) | 0.99 | M | −0.23 (0.01) | 0.04 | |
ELP3 | 4 | rs13253111 | G | −0.13 (0.10) | 0.20 | −0.07 (0.20) | 0.73 | −0.02 (0.01) | 0.12 |
RAB27B | 2 | rs8092503 | G | 0.05 (0.11) | 0.66 | 0.13 (0.28) | 0.66 | 0.02 (0.02) | 0.17 |
GPR61 | 4 | rs7550711 | T | −0.31 (0.65) | 0.64 | M | 0.15 (0.012) | 0.20 | |
TNNI3K | 8 | rs12041852 | A | 0.07 (0.11) | 0.53 | 0.67 (0.42) | 0.12 | −0.01 (0.01) | 0.54 |
NMM/Yaquis (n = 301) | Seris (n = 68) | CM (n = 8545) | |||||||
---|---|---|---|---|---|---|---|---|---|
Gene | Chr | SNP | AA | OR (CI) | p | OR (CI) | p | OR (CI) | p |
SEC16B | 1 | rs543874 | G | 1.79 (1.04, 3.08) | 0.04 | 0.31 (0.08, 1.24) | 0.09 | 1.26 (1.13, 1.32) | 1.0 × 10−5 |
OLFM4 | 13 | rs12429545 | G | 0.84 (0.53, 1.34) | 0.47 | 0.44 (0.13, 1.65) | 0.21 | 0.85 (0.78, 0.93) | 2.2 × 10−4 |
FTO | 16 | rs9939609 | A | 0.93 (0.55, 1.57) | 0.78 | 2.17 (0.43, 10.87) | 0.34 | 1.26 (1.12 1.42) | 2.2 × 10−4 |
MC4R | 18 | rs6567160 | C | 1.73 (0.79, 3.81) | 0.17 | 1.00 (0.08, 11.99) | 1.00 | 1.25 (1.06, 1.48) | 8.0 × 10−3 |
GNPDA2 | 4 | rs13130484 | T | 0.86 (0.54, 1.36) | 0.52 | 1.43 (0.63, 3.25) | 0.40 | 1.12 (1.01, 1.21) | 0.03 |
OLFM4 | 13 | rs9568856 | G | 1.04 (0.67, 1.59) | 0.87 | 0.78 (0.28, 2.11) | 0.62 | 0.90 (0.82, 0.98) | 0.01 |
FAIM2 | 12 | rs7132908 | A | 0.91 (0.52, 1.57) | 0.73 | 1.41 (0.32, 6.08) | 0.65 | 1.048 (0.93, 1.18) | 0.46 |
FAM120AOS | 9 | rs944990 | A | 0.96 (0.57, 1.59) | 0.78 | 0.42 (0.12, 1.46) | 0.17 | 1.076 (0.97, 1.19) | 0.17 |
LMX1B | 9 | rs3829849 | A | 0.92 (0.53, 1.58) | 0.51 | 0.73 (0.15, 3.68) | 0.71 | 1.18 (1.02, 1.37) | 0.03 |
ADAM23 | 2 | rs13387838 | A | 1.52 (0.44, 5.27) | 0.78 | M | 1.45 (0.81, 2.58) | 0.21 | |
HOXB5 | 17 | rs9299 | G | 0.94 (0.60, 1.46) | 0.77 | 0.54 (0.20, 1.43) | 0.21 | 0.94 (0.86, 1.02) | 0.14 |
ELP3 | 8 | rs13253111 | G | 0.61 (0.39, 0.94) | 0.33 | 0.86 (0.36, 2.07) | 0.74 | 0.94 (0.86, 1.03) | 0.20 |
RAB27B | 18 | rs8092503 | G | 1.24 (0.81, 1.90) | 1.00 | 0.42 (0.08, 2.16) | 0.30 | 1.04 (0.96, 1.14) | 0.33 |
GPR61 | 1 | rs7550711 | T | VLF | M | 1.03 (0.52, 2.04) | 0.93 | ||
TNNI3K | 1 | rs12041852 | A | 1.18 (0.74, 1.88) | 0.48 | 4.35 (0.77, 24.43) | 0.09 | 0.97 (0.88, 1.07) | 0.54 |
Variables | β | SE | p |
---|---|---|---|
Intercept | −0.01 | 0.01 | 0.26 |
GRS | 0.11 | 0.01 | 0.1 × 10−16 |
AMA | −0.05 | 0.01 | 6.8 × 10−7 |
GRS*AMA | 0.03 | 0.01 | 6.0 × 10−3 |
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Costa-Urrutia, P.; Abud, C.; Franco-Trecu, V.; Colistro, V.; Rodríguez-Arellano, M.E.; Alvarez-Fariña, R.; Acuña Alonso, V.; Bertoni, B.; Granados, J. Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children. Int. J. Mol. Sci. 2020, 21, 374. https://doi.org/10.3390/ijms21020374
Costa-Urrutia P, Abud C, Franco-Trecu V, Colistro V, Rodríguez-Arellano ME, Alvarez-Fariña R, Acuña Alonso V, Bertoni B, Granados J. Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children. International Journal of Molecular Sciences. 2020; 21(2):374. https://doi.org/10.3390/ijms21020374
Chicago/Turabian StyleCosta-Urrutia, Paula, Carolina Abud, Valentina Franco-Trecu, Valentina Colistro, Martha Eunice Rodríguez-Arellano, Rafael Alvarez-Fariña, Víctor Acuña Alonso, Bernardo Bertoni, and Julio Granados. 2020. "Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children" International Journal of Molecular Sciences 21, no. 2: 374. https://doi.org/10.3390/ijms21020374