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Article

Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children

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Laboratorio de Medicina Genómica del Hospital Regional Lic. Adolfo López Mateos, ISSSTE, Ciudad de México 01030, Mexico
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Integrigen de Mexico SAPI de CV. Patriotismo 12, Ciudad de México 06100, Mexico
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Departamento de Ecología y Evolución, Facultad de Ciencias, Universidad de la República. Iguá 4225, Montevideo 11400, Uruguay
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Departamento de Métodos Cuantitativos, Facultad de Medicina, Universidad de la República. Avda. General Flores 2125, Montevideo 11800, Uruguay
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Instituto Nacional de Antropología e Historia. Periférico Sur y Zapote, Tlalpan, Ciudad de México 14030, Mexico
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Departamento de Genetica, Facultad de Medicina, Universidad de la República. Avda. General Flores 2125, Montevideo 11800, Uruguay
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División de Inmunogenética, Departamento de Trasplantes, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Avda. Vasco de Quiroga, Ciudad de México14080, Mexico
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(2), 374; https://doi.org/10.3390/ijms21020374
Received: 13 November 2019 / Revised: 20 December 2019 / Accepted: 3 January 2020 / Published: 7 January 2020
(This article belongs to the Section Molecular Genetics and Genomics)
In Mexico, the genetic mechanisms underlying childhood obesity are poorly known. We evaluated the effect of loci, known to be associated with childhood body mass index (BMI) in Europeans, in Mexican children from different ethnic groups. We performed linear and logistic analyses of BMI and obesity, respectively, in Mestizos and Amerindians (Seris, Yaquis and Nahuatl speakers) from Northern (n = 369) and Central Mexico (n = 8545). We used linear models to understand the effect of degree of Amerindian ancestry (AMA) and genetic risk score (GRS) on BMI z-score. Northern Mexican Mestizos showed the highest overweight-obesity prevalence (47.4%), followed by Seri (36.2%) and Central Mexican (31.5%) children. Eleven loci (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2/rs13130484, FAIM2/rs7132908, FAM120AOS/rs944990, LMX1B/rs3829849, ADAM23/rs13387838, HOXB5/rs9299) were associated with BMI and seven (SEC16B/rs543874, OLFM4/rs12429545/rs9568856, FTO/rs9939609, MC4R/rs6567160, GNPDA2 rs13130484, LMX1B/rs3829849) were associated with obesity in Central Mexican children. One SNP was associated with obesity in Northern Mexicans and Yaquis (SEC16B/rs543874). We found higher BMI z-score at higher GRS (β = 0.11, p = 0.2 × 10−16) and at lower AMA (β = −0.05, p = 6.8 × 10−7). The GRS interacts with AMA to increase BMI (β = 0.03, p = 6.08 × 10−3). High genetic BMI susceptibility increase the risk of higher BMI, including in Amerindian children. View Full-Text
Keywords: genetic susceptibility; BMI; childhood obesity; Amerindian ancestry genetic susceptibility; BMI; childhood obesity; Amerindian ancestry
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MDPI and ACS Style

Costa-Urrutia, P.; Abud, C.; Franco-Trecu, V.; Colistro, V.; Rodríguez-Arellano, M.E.; Alvarez-Fariña, R.; Acuña Alonso, V.; Bertoni, B.; Granados, J. Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children. Int. J. Mol. Sci. 2020, 21, 374. https://doi.org/10.3390/ijms21020374

AMA Style

Costa-Urrutia P, Abud C, Franco-Trecu V, Colistro V, Rodríguez-Arellano ME, Alvarez-Fariña R, Acuña Alonso V, Bertoni B, Granados J. Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children. International Journal of Molecular Sciences. 2020; 21(2):374. https://doi.org/10.3390/ijms21020374

Chicago/Turabian Style

Costa-Urrutia, Paula; Abud, Carolina; Franco-Trecu, Valentina; Colistro, Valentina; Rodríguez-Arellano, Martha E.; Alvarez-Fariña, Rafael; Acuña Alonso, Víctor; Bertoni, Bernardo; Granados, Julio. 2020. "Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children" Int. J. Mol. Sci. 21, no. 2: 374. https://doi.org/10.3390/ijms21020374

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