Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility
Abstract
:1. Introduction
2. Methods
2.1. Sources
2.2. Study Selection
3. Results
3.1. Seminal Plasma Transcriptome
3.1.1. Implication in Male Infertility
3.1.2. Conclusion
3.2. Seminal Plasma Proteome
3.2.1. Implication in Male Infertility
3.2.2. Conclusion
4. The Future of Seminal Plasma Biomarkers in Male Infertility
Funding
Conflicts of Interest
References
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Authors | Population | Results |
---|---|---|
[31] | 118 patients with NOA and 168 fertile controls | Down-regulated miRNAs: hsa-miR-34c; hsa-miR-122; hsa-miR-509-5p |
[23] | 96 idiopathic infertile patients (48 with oligozoospermia and 48 with NOA) and 48 fertile controls | Up-regulated miRNAs: miR-19b and let-7a |
[27] | 100 patients with NOA and 100 fertile controls | Up-regulated miRNAs: miR-141, miR-429 and miR-7-1-3p |
[22] | 211 infertile patients (AT or azoospermia) and 91 fertile controls | Down-regulated piRNAs: piR-31068, piR-31925, piR-43771, piR-43773 and piR-31098 |
[18] | 1378 patients with idiopathic infertility and 486 fertile controls | Down-regulated miRNA: miR-196a-5p |
[26] | 14 patients with NOA, 13 with OA and 9 normozoospermic controls | Down-regulated miRNAs (NOA): hsa-miR-202-3p; hsa-miR-514a-3p; hsa-miR-202-5p; hsa-miR-510-3-5p; hsa-miR-509-3-5p; hsa-miR-510-5p; hsa-miR-513c-5p; hsa-miR-518e-3p; hsa-miR-508-5p; hsa-miR-520h; hsa-miR-9-3p; hsa-miR-506-3p; hsa-miR-383-5p; hsa-miR-34c-5p; hsa-miR-517c-3p; hsa-miR-873-5p; hsa-miR-34b-5p; hsa-miR-513a-3p; hsa-miR-52; hsa-miR-452-5p; hsa-miR-122-5p; hsa-miR-449a; hsa-miR-449a-5p; hsa-miR-455-5p; has-miR-9-5p; 132-5p; hsa hsa-miR-203a Up-regulated miRNAs (NOA): hsa-miR-363-5p; hsa-miR-365a-3p; hsa-miR-550a-5p; 423-5p; hsa-miR-153-3p; hsa-miR-196b-3p; hsa-miR-96-5p; hsa-let-7-1-3p Down-regulated miRNAs (OA): hsa-miR-202-3p; hsa-miR-514a-3p; hsa-miR-202-5p; hsa-miR-510-3-5p; hsa-miR-509-3-5p; hsa-miR-510-5p; hsa-miR-513c-5p; hsa-miR-518e-3p; hsa-miR-508-5p; hsa-miR-520h; hsa-miR-9-3p; hsa-miR-506-3p; hsa-miR-383-5p; hsa-miR-34c-5p; hsa-miR-517-3p; hsa-miR-873-5p; hsa -miR-34b-5p; hsa -miR-513-3p; hsa -miR-52; hsa -miR-452-5p; hsa -miR-122-5p; hsa -miR-449a; hsa -miR-449a-5p; hsa -miR-455-5p; hsa -miR-819b; hsa -miR-890; hsa -miR-34c-3p; hsa -miR-891a-5p; hsa -miR-888-5p; hsa -miR-124-3p; hsa -miR-892a; hsa -miR-551b-3p; hsa -miR-424-5p; hsa -miR-181b-5p; hsa -miR-31-3p; hsa -miR-181a-5p; hsa -miR-31-5p; hsa -miR-10b-3p; hsa -miR-222-3p; hsa -miR-455-3p; hsa -miR-205-5p; hsa -miR-182-3p; hsa-miR-95-3p Up-regulated miRNAs (OA): hsa -miR-363-3p; hsa -miR-365a-3p; hsa -miR-29a-3p; hsa-miR-296-5p; hsa-miR-23b-5p; hsa-miR-21-3p; hsa-miR-193a-3p; hsa-miR-29c-3p; hsa-miR-361-3p |
[19] | 30 infertile patients with high sperm DFI and 30 fertile controls | Up-regulated miRNA: miR-424 |
[32] | 40 patients with KS, 60 with NOA, 60 OA and 40 normozoospermic controls | Down-regulated miRNAs: has-miR-509-5p; has-miR-122-5p; has-miR-34b-3p; has-miR-34c-5p |
[33] | 17 patients with AT, 15 patients with teratozoospermia, 17 patients with AT, 18 normozoospermic infertile patients | Up-regulated miRNA: miRNA-582-5p (teratozoospermia and AT) |
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Cannarella, R.; Barbagallo, F.; Crafa, A.; La Vignera, S.; Condorelli, R.A.; Calogero, A.E. Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility. Int. J. Mol. Sci. 2020, 21, 7308. https://doi.org/10.3390/ijms21197308
Cannarella R, Barbagallo F, Crafa A, La Vignera S, Condorelli RA, Calogero AE. Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility. International Journal of Molecular Sciences. 2020; 21(19):7308. https://doi.org/10.3390/ijms21197308
Chicago/Turabian StyleCannarella, Rossella, Federica Barbagallo, Andrea Crafa, Sandro La Vignera, Rosita A. Condorelli, and Aldo E. Calogero. 2020. "Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility" International Journal of Molecular Sciences 21, no. 19: 7308. https://doi.org/10.3390/ijms21197308