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Open AccessArticle

A Rare Natural Benzo[k,l]xanthene as a Turn-Off Fluorescent Sensor for Cu2+ Ion

1
Department of Drug Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
2
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
*
Authors to whom correspondence should be addressed.
Dedicated to Professor Carmela Spatafora, a friend, colleague, and distinguished scientist, who prematurely passed away during the preparation of the paper.
Int. J. Mol. Sci. 2020, 21(18), 6933; https://doi.org/10.3390/ijms21186933
Received: 31 July 2020 / Revised: 17 September 2020 / Accepted: 18 September 2020 / Published: 21 September 2020
(This article belongs to the Section Molecular Biophysics)
Rapid and efficient analyses of copper ions are crucial to providing key information for Cu2+ in living cells because of their biological importance. In this study, we reported one new turn-off fluorescent sensor for Cu2+ with a benzo[k,l]xanthene core, which served as an efficient cation sensor for copper ion over a wide range of other cations (Na+, K+, Ag+, Hg2+, Cd2+, Co2+, Ni2+, Zn2+, Mg2+, and Fe3+) owing to the catechol group in the aromatic core. The sensor showed selectivity for Cu2+ over other ions; the logKβ for Cu2+ binding to compound 1 had a value of 13.265. In the presence of Cu2+, sensor 1 provided significant fluorescence decrement; Co2+, and Ni2+ caused a fluorescence decrement when employed at a higher concentration than Cu2+, while Na+, K+, Hg2+, Cd2+, Zn2+, and Mg2+ metal ions produced only minor changes in fluorescence intensity. Fluorescence experiments demonstrate that compound 1 may have an application as a fluorescent probe for detecting Cu2+ with a limit of detection of 0.574 µM. View Full-Text
Keywords: polyphenols; lignans; fluorescent sensor; natural-derived ligand polyphenols; lignans; fluorescent sensor; natural-derived ligand
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MDPI and ACS Style

Floresta, G.; Cardullo, N.; Spatafora, C.; Rescifina, A.; Tringali, C. A Rare Natural Benzo[k,l]xanthene as a Turn-Off Fluorescent Sensor for Cu2+ Ion. Int. J. Mol. Sci. 2020, 21, 6933.

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