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Article

Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study

1
Department of Psychiatry, Hospital Sierrallana, IDIVAL, CIBERSAM, School of Medicine, University of Cantabria, 39300 Torrelavega, Spain
2
Department of Immunology, Hospital Universitario A Coruña, 15006 A Coruña, Spain
3
Department of Psychiatry, Hospital Universitario Marqués de Valdecilla, IDIVAL, CIBERSAM, School of Medicine, University of Cantabria, 39008 Santander, Spain
4
Department of Psychiatry, Hospital Universitario Virgen del Rocío, Instituto de Investigacion Sanitaria de Sevilla (IBiS), CIBERSAM, School of Medicine, University of Sevilla, 41013 Sevilla, Spain
5
Department of Pharmacology & Toxicology, Faculty of Medicine, Complutense University (UCM), Instituto de Investigación Sanitaria (IIS) Hospital 12 de Octubre (i+12), and IUIN-UCM, CIBERSAM, 28040 Madrid, Spain
6
Department of Immunology, Hospital Universitario Marqués de Valdecilla, PI of “Transplant and Autoimmunity” Research Group, REDINREN RD16/0009/0027, IDIVAL, School of Medicine, University of Cantabria, 39008 Santander, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(17), 6106; https://doi.org/10.3390/ijms21176106
Received: 29 July 2020 / Revised: 19 August 2020 / Accepted: 22 August 2020 / Published: 25 August 2020
(This article belongs to the Special Issue Immunology of Neuropsychiatric Disorders)
Toll-like receptors (TLRs) are a pivotal component of the innate immune system that seem to have a role in the pathogenesis of psychosis. The purpose of this work was to compare the expression and functionality of 9 TLRs in three peripheral blood mononuclear cells (PBMCs) (monocytes, B cells, and T cells) between 33 drug-naïve first-episode psychosis (FEP) individuals and 26 healthy volunteers, at baseline and after 3-month of antipsychotic treatment. The expression of TLRs 1–9 were assessed by flow cytometry. For the assessment of the TLR functionality, cells collected in sodium heparin tubes were polyclonally stimulated for 18 h, with different agonists for human TLR1–9. The results of our study highlight the role that TLR5 and TLR8 might play in the pathophysiology of psychosis. We found a lower expression of these receptors in FEP individuals, regarding healthy volunteers at baseline and after 3-month of treatment on the three PBMCs subsets. Most TLRs showed a lower functionality (especially reduced intracellular levels of TNF-α) in patients than in healthy volunteers. These results, together with previous evidence, suggest that individuals with psychosis might show a pattern of TLR expression that differs from that of healthy volunteers, which could vary according to the intensity of immune/inflammatory response. View Full-Text
Keywords: psychosis; neuroinflammation; toll-like receptors; cytokines psychosis; neuroinflammation; toll-like receptors; cytokines
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MDPI and ACS Style

Juncal-Ruiz, M.; Riesco-Davila, L.; Vazquez-Bourgon, J.; Ortiz-Garcia de la Foz, V.; Mayoral-Van Son, J.; Ayesa-Arriola, R.; Setien-Suero, E.; Leza, J.C.; Lopez-Hoyos, M.; Crespo-Facorro, B. Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study. Int. J. Mol. Sci. 2020, 21, 6106. https://doi.org/10.3390/ijms21176106

AMA Style

Juncal-Ruiz M, Riesco-Davila L, Vazquez-Bourgon J, Ortiz-Garcia de la Foz V, Mayoral-Van Son J, Ayesa-Arriola R, Setien-Suero E, Leza JC, Lopez-Hoyos M, Crespo-Facorro B. Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study. International Journal of Molecular Sciences. 2020; 21(17):6106. https://doi.org/10.3390/ijms21176106

Chicago/Turabian Style

Juncal-Ruiz, Maria, Laura Riesco-Davila, Javier Vazquez-Bourgon, Victor Ortiz-Garcia de la Foz, Jacqueline Mayoral-Van Son, Rosa Ayesa-Arriola, Esther Setien-Suero, Juan C. Leza, Marcos Lopez-Hoyos, and Benedicto Crespo-Facorro. 2020. "Expression and Functionality Study of 9 Toll-Like Receptors in 33 Drug-Naïve Non-Affective First Episode Psychosis Individuals: A 3-Month Study" International Journal of Molecular Sciences 21, no. 17: 6106. https://doi.org/10.3390/ijms21176106

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