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There and Back Again: Leptin Actions in White Adipose Tissue

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK
Int. J. Mol. Sci. 2020, 21(17), 6039; https://doi.org/10.3390/ijms21176039
Received: 31 July 2020 / Revised: 17 August 2020 / Accepted: 18 August 2020 / Published: 21 August 2020
(This article belongs to the Special Issue Leptin)
Leptin is a hormone discovered almost 30 years ago with important implications in metabolism. It is primarily produced by white adipose tissue (WAT) in proportion to the amount of fat. The discovery of leptin was a turning point for two principle reasons: on one hand, it generated promising expectations for the treatment of the obesity, and on the other, it changed the classical concept that white adipose tissue was simply an inert storage organ. Thus, adipocytes in WAT produce the majority of leptin and, although its primary role is the regulation of fat stores by controlling lipolysis and lipogenesis, this hormone also has implications in other physiological processes within WAT, such as apoptosis, browning and inflammation. Although a massive number of questions related to leptin actions have been answered, the necessity for further clarification facilitates constantly renewing interest in this hormone and its pathways. In this review, leptin actions in white adipose tissue will be summarized in the context of obesity. View Full-Text
Keywords: leptin; white adipose tissue; obesity leptin; white adipose tissue; obesity
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MDPI and ACS Style

Martínez-Sánchez, N. There and Back Again: Leptin Actions in White Adipose Tissue. Int. J. Mol. Sci. 2020, 21, 6039. https://doi.org/10.3390/ijms21176039

AMA Style

Martínez-Sánchez N. There and Back Again: Leptin Actions in White Adipose Tissue. International Journal of Molecular Sciences. 2020; 21(17):6039. https://doi.org/10.3390/ijms21176039

Chicago/Turabian Style

Martínez-Sánchez, Noelia. 2020. "There and Back Again: Leptin Actions in White Adipose Tissue" Int. J. Mol. Sci. 21, no. 17: 6039. https://doi.org/10.3390/ijms21176039

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