Next Article in Journal
Functional Imaging for Therapeutic Assessment and Minimal Residual Disease Detection in Multiple Myeloma
Next Article in Special Issue
Indoleamine 2,3-Dioxygenase 2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation
Previous Article in Journal
Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction
Previous Article in Special Issue
Changes in Proteome of Fibroblasts Isolated from Psoriatic Skin Lesions

Nutrition and Psoriasis

Department of Dermatology, Nippon Medical School, Chiba Hokusoh Hospital, Inzai, Chiba 270-1694, Japan
Department of Dermatology, Nippon Medical School, Bunkyo-Ku, Tokyo 113-8602, Japan
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5405;
Received: 14 July 2020 / Revised: 26 July 2020 / Accepted: 27 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated)
Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor necrosis factor-α/interleukin-23/interleukin-17 axis, hyperproliferation and abnormal differentiation of epidermal keratinocytes. Psoriasis patients are frequently associated with obesity, diabetes, dyslipidemia, cardiovascular diseases, or inflammatory bowel diseases. Psoriasis patients often show unbalanced dietary habits such as higher intake of fat and lower intake of fish or dietary fibers, compared to controls. Such dietary habits might be related to the incidence and severity of psoriasis. Nutrition influences the development and progress of psoriasis and its comorbidities. Saturated fatty acids, simple sugars, red meat, or alcohol exacerbate psoriasis via the activation of nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 inflammasome, tumor necrosis factor-α/interleukin-23/interleukin-17 pathway, reactive oxygen species, prostanoids/leukotrienes, gut dysbiosis or suppression of regulatory T cells, while n-3 polyunsaturated fatty acids, vitamin D, vitamin B12, short chain fatty acids, selenium, genistein, dietary fibers or probiotics ameliorate psoriasis via the suppression of inflammatory pathways above or induction of regulatory T cells. Psoriasis patients are associated with dysbiosis of gut microbiota and the deficiency of vitamin D or selenium. We herein present the update information regarding the stimulatory or regulatory effects of nutrients or food on psoriasis and the possible alleviation of psoriasis by nutritional strategies. View Full-Text
Keywords: psoriasis; nutrition; interleukin-17; vitamin D; n-3 polyunsaturated fatty acid; saturated fatty acid; short chain fatty acid; regulatory T cell; dysbiosis psoriasis; nutrition; interleukin-17; vitamin D; n-3 polyunsaturated fatty acid; saturated fatty acid; short chain fatty acid; regulatory T cell; dysbiosis
Show Figures

Figure 1

MDPI and ACS Style

Kanda, N.; Hoashi, T.; Saeki, H. Nutrition and Psoriasis. Int. J. Mol. Sci. 2020, 21, 5405.

AMA Style

Kanda N, Hoashi T, Saeki H. Nutrition and Psoriasis. International Journal of Molecular Sciences. 2020; 21(15):5405.

Chicago/Turabian Style

Kanda, Naoko, Toshihiko Hoashi, and Hidehisa Saeki. 2020. "Nutrition and Psoriasis" International Journal of Molecular Sciences 21, no. 15: 5405.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop