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Open AccessCommunication

Overexpressed BSR1-Mediated Enhancement of Disease Resistance Depends on the MAMP-Recognition System

1
Institute of Agrobiological Sciences, NARO (NIAS), Tsukuba 305-8602, Japan
2
Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda 278-8510, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5397; https://doi.org/10.3390/ijms21155397
Received: 22 June 2020 / Revised: 22 July 2020 / Accepted: 26 July 2020 / Published: 29 July 2020
(This article belongs to the Special Issue Nutrients and Disease Resistance in Plants)
Plant plasma membrane-localized receptors recognize microbe-associated molecular patterns (MAMPs) and activate immune responses via various signaling pathways. Receptor-like cytoplasmic kinases (RLCKs) are considered key signaling factors in plant immunity. BROAD-SPECTRUM RESISTANCE 1 (BSR1), a rice RLCK, plays a significant role in disease resistance. Overexpression of BSR1 confers strong resistance against fungal and bacterial pathogens. Our recent study revealed that MAMP-triggered immune responses are mediated by BSR1 in wild-type rice and are hyperactivated in BSR1-overexpressing rice. It was suggested that hyperactivated immune responses were responsible for the enhancement of broad-spectrum disease resistance; however, this remained to be experimentally validated. In this study, we verified the above hypothesis by disrupting the MAMP-recognition system in BSR1-overexpressing rice. To this end, we knocked out OsCERK1, which encodes a well-characterized MAMP-receptor-like protein kinase. In the background of BSR1 overaccumulation, the knockout of OsCERK1 nearly abolished the enhancement of blast resistance. This finding indicates that overexpressed BSR1-mediated enhancement of disease resistance depends on the MAMP-triggered immune system, corroborating our previously suggested model. View Full-Text
Keywords: disease resistance; microbe-associated molecular pattern (MAMP); Pyricularia oryzae (formerly Magnaporthe oryzae); Oryza sativa (rice); receptor-like cytoplasmic kinase (RLCK) disease resistance; microbe-associated molecular pattern (MAMP); Pyricularia oryzae (formerly Magnaporthe oryzae); Oryza sativa (rice); receptor-like cytoplasmic kinase (RLCK)
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Kanda, Y.; Nishizawa, Y.; Kamakura, T.; Mori, M. Overexpressed BSR1-Mediated Enhancement of Disease Resistance Depends on the MAMP-Recognition System. Int. J. Mol. Sci. 2020, 21, 5397.

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