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Article

Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model

1
Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
2
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02435, Korea
3
Division of RI-Convergence Research, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(14), 4901; https://doi.org/10.3390/ijms21144901
Received: 24 April 2020 / Revised: 1 July 2020 / Accepted: 9 July 2020 / Published: 11 July 2020
(This article belongs to the Special Issue Neuroprotection: Rescue from Neuronal Death in the Brain)
Background: Trimethyltin (TMT) is a potent neurotoxin affecting various regions of the central nervous system, including the neocortex, the cerebellum, and the hippocampus. Phosphatidylserine (PS) is a membrane phospholipid, which is vital to brain cells. We analyzed the neuroprotective effects of soybean-derived phosphatidylserine (Bean-PS) on cognitive function, changes in the central cholinergic systems, and neural activity in TMT-induced memory deficits in a rat model. Methods: The rats were randomly divided into an untreated normal group, a TMT group (injected with TMT + vehicle), and a group injected with TMT + Bean-PS. The rats were treated with 10% hexane (TMT group) or TMT + Bean-PS (50 mg·kg−1, oral administration (p.o.)) daily for 21 days, following a single injection of TMT (8.0 mg/kg, intraperitoneally (i.p.)). The cognitive function of Bean-PS was assessed using the Morris water maze (MWM) test and a passive avoidance task (PAT). The expression of acetylcholine transferase (ChAT) and acetylcholinesterase (AchE) in the hippocampus was assessed via immunohistochemistry. A positron emission tomography (PET) scan was used to measure the glucose uptake in the rat brain. Results: Treatment with Bean-PS enhanced memory function in the Morris water maze (MWM) test. Consistent with the behavioral results, treatment with Bean-PS diminished the damage to cholinergic cells in the hippocampus, in contrast to those of the TMT group. The TMT+Bean-PS group showed elevated glucose uptake in the frontal lobe of the rat brain. Conclusion: These results demonstrate that Bean-PS protects against TMT-induced learning and memory impairment. As such, Bean-PS represents a potential treatment for neurodegenerative disorders, such as Alzheimer’s disease. View Full-Text
Keywords: neuroprotection; neurodegenerative disorder; choline acetyltransferase (ChAT); trimethyltin (TMT); bean phosphatidylserine (Bean-PS) neuroprotection; neurodegenerative disorder; choline acetyltransferase (ChAT); trimethyltin (TMT); bean phosphatidylserine (Bean-PS)
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MDPI and ACS Style

Ye, M.; Han, B.H.; Kim, J.S.; Kim, K.; Shim, I. Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model. Int. J. Mol. Sci. 2020, 21, 4901. https://doi.org/10.3390/ijms21144901

AMA Style

Ye M, Han BH, Kim JS, Kim K, Shim I. Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model. International Journal of Molecular Sciences. 2020; 21(14):4901. https://doi.org/10.3390/ijms21144901

Chicago/Turabian Style

Ye, Minsook, Bong H. Han, Jin S. Kim, Kyungsoo Kim, and Insop Shim. 2020. "Neuroprotective Effect of Bean Phosphatidylserine on TMT-Induced Memory Deficits in a Rat Model" International Journal of Molecular Sciences 21, no. 14: 4901. https://doi.org/10.3390/ijms21144901

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