Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration
1
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
Center for Lipid Biosciences, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
4
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5
Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan
6
Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan
7
Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan
9
Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
10
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
11
Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
12
Departments of Orthopedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
13
Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 807, Taiwan
14
Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
15
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(13), 4770; https://doi.org/10.3390/ijms21134770
Received: 10 June 2020
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Revised: 1 July 2020
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Accepted: 3 July 2020
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Published: 5 July 2020
(This article belongs to the Special Issue Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration 2.0)
Mesenchymal stem cells (MSCs) have two characteristics of interest for this paper: the ability to self-renew, and the potential for multiple-lineage differentiation into various cells. MSCs have been used in cardiac tissue regeneration for over a decade. Adult cardiac tissue regeneration ability is quite low; it cannot repair itself after injury, as the heart cells are replaced by fibroblasts and lose function. It is therefore important to search for a feasible way to repair and restore heart function through stem cell therapy. Stem cells can differentiate and provide a source of progenitor cells for cardiomyocytes, endothelial cells, and supporting cells. Studies have shown that the concentrations of blood lipids and lipoproteins affect cardiovascular diseases, such as atherosclerosis, hypertension, and obesity. Furthermore, the MSC lipid profiles, such as the triglyceride and cholesterol content, have been revealed by lipidomics, as well as their correlation with MSC differentiation. Abnormal blood lipids can cause serious damage to internal organs, especially heart tissue. In the past decade, the accumulated literature has indicated that lipids/lipoproteins affect stem cell behavior and biological functions, including their multiple lineage capability, and in turn affect the outcome of regenerative medicine. This review will focus on the effect of lipids/lipoproteins on MSC cardiac regenerative medicine, as well as the effect of lipid-lowering drugs in promoting cardiomyogenesis-associated MSC differentiation.
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Keywords:
cardiac tissue regeneration; lipid; lipid-lowering drug; lipoprotein; mesenchymal stem cell; Simvastatin
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MDPI and ACS Style
Lin, Y.-H.; Kang, L.; Feng, W.-H.; Cheng, T.-L.; Tsai, W.-C.; Huang, H.-T.; Lee, H.-C.; Chen, C.-H. Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration. Int. J. Mol. Sci. 2020, 21, 4770. https://doi.org/10.3390/ijms21134770
AMA Style
Lin Y-H, Kang L, Feng W-H, Cheng T-L, Tsai W-C, Huang H-T, Lee H-C, Chen C-H. Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration. International Journal of Molecular Sciences. 2020; 21(13):4770. https://doi.org/10.3390/ijms21134770
Chicago/Turabian StyleLin, Yi-Hsiung, Lin Kang, Wen-Han Feng, Tsung-Lin Cheng, Wei-Chung Tsai, Hsuan-Ti Huang, Hsiang-Chun Lee, and Chung-Hwan Chen. 2020. "Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration" International Journal of Molecular Sciences 21, no. 13: 4770. https://doi.org/10.3390/ijms21134770
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