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Open AccessReview

Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age

1
Clinica Nefrologica, Ospedale Policlinico San Martino, Dipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, 16132 Genova, Italy
2
Clinica di Medicina Interna 2, Ospedale Policlinico San Martino, Dipartimento di Medicina Interna e Specialità Mediche, Università degli Studi di Genova, 16132 Genova, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(12), 4479; https://doi.org/10.3390/ijms21124479
Received: 20 May 2020 / Revised: 19 June 2020 / Accepted: 22 June 2020 / Published: 24 June 2020
Recently, there has been a growing interest in epidemiological and clinical studies supporting a pathogenetic role of fructose in cardio-metabolic diseases, especially in children and adolescents. In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age. View Full-Text
Keywords: fructose; uric acid; URAT-1; cardiovascular risk; children; metabolic syndrome; hypertension; NAFLD fructose; uric acid; URAT-1; cardiovascular risk; children; metabolic syndrome; hypertension; NAFLD
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MDPI and ACS Style

Russo, E.; Leoncini, G.; Esposito, P.; Garibotto, G.; Pontremoli, R.; Viazzi, F. Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age. Int. J. Mol. Sci. 2020, 21, 4479. https://doi.org/10.3390/ijms21124479

AMA Style

Russo E, Leoncini G, Esposito P, Garibotto G, Pontremoli R, Viazzi F. Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age. International Journal of Molecular Sciences. 2020; 21(12):4479. https://doi.org/10.3390/ijms21124479

Chicago/Turabian Style

Russo, Elisa; Leoncini, Giovanna; Esposito, Pasquale; Garibotto, Giacomo; Pontremoli, Roberto; Viazzi, Francesca. 2020. "Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age" Int. J. Mol. Sci. 21, no. 12: 4479. https://doi.org/10.3390/ijms21124479

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