ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke
Abstract
:1. Introduction
2. Results
2.1. ABCA1-B/-B Mice Exhibit Reduced Myelination in the WM Area
2.2. ABCA1-B/-B Stroke Mice did not Exhibit Change in the Ischemic Lesion Volume but Show Decreased Functional Outcome Compared with ABCA1fl/f Stroke Mice; Administration of HDL3 or ApoE2 in ABCA1-B/-B Stroke Mice Attenuated ABCA1-B/-B-Induced Functional Deficits 14 and 21 Days after Stroke
2.3. ABCA1-B/-B Decreased Myelination in the CC of Ischemic Boundary Zone (IBZ) after Stroke; Administration of HDL3 or ApoE2 Attenuated the Deficits in the Myelination in the CC of IBZ in ABCA1-B/-B Stroke Mice
2.4. ABCA1-B/-B Stroke Mice Exhibit Decreased Oligodendrogenesis Compared to ABCA1fl/fl Stroke Mice; Administration of HDL3 or ApoE2 Significantly Attenuated the Reduced Oligodendrogenesis in the IBZ of ABCA1-B/-B After Stroke
2.5. ABCA1-B/-B Reduced ApoE and HDL Levels in OPCs
2.6. OPCs Derived from ABCA1-B/-B Mice Exhibit Decreased Migration Compared with OPCs Derived from ABCA1fl/fl Mice; HDL3 and ApoE2 Treatment Significantly Increase OPC Migration of OPCs Derived from ABCA1-B/-B Mice
2.7. ABCA1-B/-B Reduced Maturation of OLs; HDL3 and ApoE2 Treatment Significantly Increase Maturation of OLs
3. Discussion
4. Materials and Methods
4.1. Experimental Groups and dMCAo Model
4.2. Behavioal Testing
4.3. Lesion Volume Measurement
4.4. Quantification of Myelination on EM Images
4.5. Immunohistostaining
4.6. Preparation of OPCs
4.7. OPC Migration Measurement
4.8. OL Maturation Measurement
4.9. RT-PCR
4.10. Western Blotting
4.11. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Li, L.; Li, R.; Zacharek, A.; Wang, F.; Landschoot-Ward, J.; Chopp, M.; Chen, J.; Cui, X. ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke. Int. J. Mol. Sci. 2020, 21, 4369. https://doi.org/10.3390/ijms21124369
Li L, Li R, Zacharek A, Wang F, Landschoot-Ward J, Chopp M, Chen J, Cui X. ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke. International Journal of Molecular Sciences. 2020; 21(12):4369. https://doi.org/10.3390/ijms21124369
Chicago/Turabian StyleLi, Li, Rongwen Li, Alex Zacharek, Fengjie Wang, Julie Landschoot-Ward, Michael Chopp, Jieli Chen, and Xu Cui. 2020. "ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke" International Journal of Molecular Sciences 21, no. 12: 4369. https://doi.org/10.3390/ijms21124369