Pleiotropic Role of Notch Signaling in Human Skin Diseases
Abstract
:1. Introduction
1.1. Core Components of Notch Signaling
1.2. Notch Signaling
1.2.1. Canonical Notch Signaling
1.2.2. Non-Canonical Notch Signaling
2. Skin
2.1. Notch Signaling and Skin
2.2. Notch and Skin
2.3. The Main Proteins Related to Notch and Skin
3. Notch Signaling and Skin Diseases
3.1. Hidradenitis Suppurativa (HS)
3.2. Dowling Degos Disease (DDD)
3.3. Adams–Oliver Syndrome (AOS)
3.4. Psoriasis
3.5. Atopic Dermatitis (AD)
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
NECD | Notch extracellular domain |
EGF-like | Epidermal growth factor-like |
NRR | Negative regulatory region |
LNR | Cysteine-rich Lin12-Notch repeats |
HD | Heterodimerization domain |
TMD | Transmembrane domain |
NICD | Intracellular domain |
RBP-Jκ | Recombination Signal Binding Protein for Immunoglobulin Kappa J Region |
RAM | Recombination Signal Binding Protein for Immunoglobulin Kappa J Region association module |
ANK | Seven ankyrin repeats |
NLS | Nuclear localization signals |
TAD | Transactivation domain |
PEST | Proline/glutamic acid/serine/threonine-rich motifs |
DSL | Delta/Serrate/Lag-2 |
DLL1 | Delta-like 1 ligand |
DLL3 | Delta-like 3 ligand |
DLL4 | Delta-like 4 ligand |
NTD | N-terminal domain |
DOS | Delta and OSM-11-like region |
CRD | Cysteine-rich domain |
PDZ | PSD-95/Dlg/ZO-1 |
GPI | Glycosylphosphatidylinositol |
NTMIC | Notch transmembrane and intracellular domain |
NEXT | Notch extracellular truncation |
Co-R | Co-repressor |
MAML | Mastermind-like |
NTC | Notch transcription complex |
HES | Hairy/enhancer of split |
HEY | Hairy/enhancer of split with YRPW motif |
CDK-8 | Cyclin-dependent kinase 8 |
MVBs | Multivesicular bodies |
HIF | Hypoxia-inducible factor |
Mef2 | Monocyte enhancer factor-2 |
IFE | Interfollicular epidermis |
ESC | Epidermal stem cells |
K1 | Keratin 1 |
K5 | Keratin 5 |
K10 | Keratin 10 |
PPARγ | Peroxisome-proliferator activated receptor |
IVL | Involucrin |
TGM | Transglutaminase |
PPL | Periplakin |
PSEN | Presenilin |
PSENEN | Presenilin enhancer-2 |
NCSTN | Nicastrin |
APH1 | Anterior pharynx defective-1 |
POFUT1 | GDP-fucose protein O-fucosyltransferase 1 |
EOGT | Epidermal growth factor domain-specific O-linked N-acetylglucosamine transferase |
POGLUT1 | Protein O-glucosyltransferase 1 |
O-GlcNAc | O-linked N-acetylglucosamine |
FILA | Filaggrin |
FLG | Filaggrin gene |
HS | Hidradenitis Suppurativa |
PI3K | Phosphoinositide 3-kinase |
AKT | Protein Kinase B |
DDD | Dowling Degos Disease |
KRT5 | Keratin 5 gene |
K14 | Ketatin 14 |
AOS | Adams–Oliver Syndrome |
ACC | Aplasia cutis congenital |
TTLD | Terminal transverse limb defects |
CTMC | Cutis marmorata telangiectatica congenita |
ARHGAP31 | Rho GTPase Activating Protein 31 |
DOCK6 | Dedicator of Cytokinesis Protein 6 |
GEF | Guanine nucleotide exchange factor |
Hrt-1 | Ring-box protein HRT1 |
A-SAA | Acute-phase Serum Amyloid A |
AD | Atopic Dermatitis |
DAPT | N-S-phenylglycine t-butylester |
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Gratton, R.; Tricarico, P.M.; Moltrasio, C.; Lima Estevão de Oliveira, A.S.; Brandão, L.; Marzano, A.V.; Zupin, L.; Crovella, S. Pleiotropic Role of Notch Signaling in Human Skin Diseases. Int. J. Mol. Sci. 2020, 21, 4214. https://doi.org/10.3390/ijms21124214
Gratton R, Tricarico PM, Moltrasio C, Lima Estevão de Oliveira AS, Brandão L, Marzano AV, Zupin L, Crovella S. Pleiotropic Role of Notch Signaling in Human Skin Diseases. International Journal of Molecular Sciences. 2020; 21(12):4214. https://doi.org/10.3390/ijms21124214
Chicago/Turabian StyleGratton, Rossella, Paola Maura Tricarico, Chiara Moltrasio, Ana Sofia Lima Estevão de Oliveira, Lucas Brandão, Angelo Valerio Marzano, Luisa Zupin, and Sergio Crovella. 2020. "Pleiotropic Role of Notch Signaling in Human Skin Diseases" International Journal of Molecular Sciences 21, no. 12: 4214. https://doi.org/10.3390/ijms21124214