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Review

Association Between Celiac Disease and Cancer

1
Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
2
Gastroenterology Unit, Policlinico Tor Vergata, 00133 Rome, Italy
3
Division of Clinical Biochemistry and Clinical Molecular Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 4155; https://doi.org/10.3390/ijms21114155
Received: 28 May 2020 / Revised: 8 June 2020 / Accepted: 9 June 2020 / Published: 10 June 2020
Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer. View Full-Text
Keywords: small bowel adenocarcinoma; T-cell lymphoma; colorectal cancer; gluten; refractory celiac disease; HLA-DQ2; HLA-DQ8; gluten-free diet small bowel adenocarcinoma; T-cell lymphoma; colorectal cancer; gluten; refractory celiac disease; HLA-DQ2; HLA-DQ8; gluten-free diet
MDPI and ACS Style

Marafini, I.; Monteleone, G.; Stolfi, C. Association Between Celiac Disease and Cancer. Int. J. Mol. Sci. 2020, 21, 4155. https://doi.org/10.3390/ijms21114155

AMA Style

Marafini I, Monteleone G, Stolfi C. Association Between Celiac Disease and Cancer. International Journal of Molecular Sciences. 2020; 21(11):4155. https://doi.org/10.3390/ijms21114155

Chicago/Turabian Style

Marafini, Irene, Giovanni Monteleone, and Carmine Stolfi. 2020. "Association Between Celiac Disease and Cancer" International Journal of Molecular Sciences 21, no. 11: 4155. https://doi.org/10.3390/ijms21114155

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