Next Article in Journal
Intracellular Ca2+ Signalling in the Pathogenesis of Acute Pancreatitis: Recent Advances and Translational Perspectives
Previous Article in Journal
Dexfenfluramine and Pergolide Cause Heart Valve Disease via Valve Metabolic Reprogramming and Ongoing Matrix Remodeling
Open AccessReview

Nanocomposites for X-Ray Photodynamic Therapy

1
The Smart Materials Research Institute, Southern Federal University, 344090 Rostov-on-Don, Russia
2
Academy of Biology and Biotechnology, Southern Federal University, 344090 Rostov-on-Don, Russia
3
Department of Oncology, National Medical Research Centre for Oncology, 344037 Rostov-on-Don, Russia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 4004; https://doi.org/10.3390/ijms21114004
Received: 23 March 2020 / Revised: 27 May 2020 / Accepted: 1 June 2020 / Published: 3 June 2020
(This article belongs to the Section Physical Chemistry and Chemical Physics)
Photodynamic therapy (PDT) has long been known as an effective method for treating surface cancer tissues. Although this technique is widely used in modern medicine, some novel approaches for deep lying tumors have to be developed. Recently, deeper penetration of X-rays into tissues has been implemented, which is now known as X-ray photodynamic therapy (XPDT). The two methods differ in the photon energy used, thus requiring the use of different types of scintillating nanoparticles. These nanoparticles are known to convert the incident energy into the activation energy of a photosensitizer, which leads to the generation of reactive oxygen species. Since not all photosensitizers are found to be suitable for the currently used scintillating nanoparticles, it is necessary to find the most effective biocompatible combination of these two agents. The most successful combinations of nanoparticles for XPDT are presented. Nanomaterials such as metal–organic frameworks having properties of photosensitizers and scintillation nanoparticles are reported to have been used as XPDT agents. The role of metal–organic frameworks for applying XPDT as well as the mechanism underlying the generation of reactive oxygen species are discussed. View Full-Text
Keywords: X-ray photodynamic therapy; photodynamic therapy; photosensitizer; scintillating nanoparticle; reactive oxygen speeches; cancer X-ray photodynamic therapy; photodynamic therapy; photosensitizer; scintillating nanoparticle; reactive oxygen speeches; cancer
Show Figures

Graphical abstract

MDPI and ACS Style

Gadzhimagomedova, Z.; Zolotukhin, P.; Kit, O.; Kirsanova, D.; Soldatov, A. Nanocomposites for X-Ray Photodynamic Therapy. Int. J. Mol. Sci. 2020, 21, 4004. https://doi.org/10.3390/ijms21114004

AMA Style

Gadzhimagomedova Z, Zolotukhin P, Kit O, Kirsanova D, Soldatov A. Nanocomposites for X-Ray Photodynamic Therapy. International Journal of Molecular Sciences. 2020; 21(11):4004. https://doi.org/10.3390/ijms21114004

Chicago/Turabian Style

Gadzhimagomedova, Zaira; Zolotukhin, Peter; Kit, Oleg; Kirsanova, Daria; Soldatov, Alexander. 2020. "Nanocomposites for X-Ray Photodynamic Therapy" Int. J. Mol. Sci. 21, no. 11: 4004. https://doi.org/10.3390/ijms21114004

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop