Next Article in Journal
Salt Stress Signals on Demand: Cellular Events in the Right Context
Next Article in Special Issue
Ambient Air Pollution Increases the Risk of Cerebrovascular and Neuropsychiatric Disorders through Induction of Inflammation and Oxidative Stress
Previous Article in Journal
How TRPC Channels Modulate Hippocampal Function
Previous Article in Special Issue
Traumatic Brain Injury and Blood–Brain Barrier (BBB): Underlying Pathophysiological Mechanisms and the Influence of Cigarette Smoking as a Premorbid Condition
Review

Cerebrovascular and Neurological Dysfunction under the Threat of COVID-19: Is There a Comorbid Role for Smoking and Vaping?

1
Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
2
Center for Blood-Brain Barrier Research, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 3916; https://doi.org/10.3390/ijms21113916
Received: 10 May 2020 / Revised: 28 May 2020 / Accepted: 29 May 2020 / Published: 30 May 2020
The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several SARS-CoV-2 positive case studies have been reported where there are mild or no symptoms of this virus. However, a selection of patients are suffering from large artery ischemic strokes. Although the pathophysiology of the SARS-CoV-2 virus affecting the cerebrovascular system has not been elucidated yet, researchers have identified several pathogenic mechanisms, including a role for the ACE2 receptor. Therefore, it is extremely crucial to identify the risk factors related to the progression and adverse outcome of cerebrovascular-neurological dysfunction in COVID-19 patients. Since many articles have reported the effect of smoking (tobacco and cannabis) and vaping in cerebrovascular and neurological systems, and considering that smokers are more prone to viral and bacterial infection compared to non-smokers, it is high time to explore the probable correlation of smoking in COVID-19 patients. Herein, we have reviewed the possible role of smoking and vaping on cerebrovascular and neurological dysfunction in COVID-19 patients, along with potential pathogenic mechanisms associated with it. View Full-Text
Keywords: SARS-CoV-2; COVID-19; cerebrovascular; neurological; smoking; CNS; blood-brain barrier SARS-CoV-2; COVID-19; cerebrovascular; neurological; smoking; CNS; blood-brain barrier
Show Figures

Figure 1

MDPI and ACS Style

Archie, S.R.; Cucullo, L. Cerebrovascular and Neurological Dysfunction under the Threat of COVID-19: Is There a Comorbid Role for Smoking and Vaping? Int. J. Mol. Sci. 2020, 21, 3916. https://doi.org/10.3390/ijms21113916

AMA Style

Archie SR, Cucullo L. Cerebrovascular and Neurological Dysfunction under the Threat of COVID-19: Is There a Comorbid Role for Smoking and Vaping? International Journal of Molecular Sciences. 2020; 21(11):3916. https://doi.org/10.3390/ijms21113916

Chicago/Turabian Style

Archie, Sabrina R.; Cucullo, Luca. 2020. "Cerebrovascular and Neurological Dysfunction under the Threat of COVID-19: Is There a Comorbid Role for Smoking and Vaping?" Int. J. Mol. Sci. 21, no. 11: 3916. https://doi.org/10.3390/ijms21113916

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop