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TRPV4: A Physio and Pathophysiologically Significant Ion Channel

How TRPC Channels Modulate Hippocampal Function

Institute of Neuroscience, Université catholique de Louvain, B-1200 Brussels, Belgium
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(11), 3915;
Received: 14 May 2020 / Revised: 27 May 2020 / Accepted: 28 May 2020 / Published: 30 May 2020
(This article belongs to the Special Issue TRP Channels)
Transient receptor potential canonical (TRPC) proteins constitute a group of receptor-operated calcium-permeable nonselective cationic membrane channels of the TRP superfamily. They are largely expressed in the hippocampus and are able to modulate neuronal functions. Accordingly, they have been involved in different hippocampal functions such as learning processes and different types of memories, as well as hippocampal dysfunctions such as seizures. This review covers the mechanisms of activation of these channels, how these channels can modulate neuronal excitability, in particular the after-burst hyperpolarization, and in the persistent activity, how they control synaptic plasticity including pre- and postsynaptic processes and how they can interfere with cell survival and neurogenesis. View Full-Text
Keywords: mGluR; working memory; spatial memory; persistent activity; afterhyperpolarization; LTP; LTD mGluR; working memory; spatial memory; persistent activity; afterhyperpolarization; LTP; LTD
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MDPI and ACS Style

Gualdani, R.; Gailly, P. How TRPC Channels Modulate Hippocampal Function. Int. J. Mol. Sci. 2020, 21, 3915.

AMA Style

Gualdani R, Gailly P. How TRPC Channels Modulate Hippocampal Function. International Journal of Molecular Sciences. 2020; 21(11):3915.

Chicago/Turabian Style

Gualdani, Roberta, and Philippe Gailly. 2020. "How TRPC Channels Modulate Hippocampal Function" International Journal of Molecular Sciences 21, no. 11: 3915.

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