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Review

Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis

1
Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche, 21066 Epalinges-Lausanne, Switzerland
2
Institut national de recherche et de sécurité (INRS), 54000 Nancy, France
3
Swiss Center for Applied Human Toxicology (SCAHT), Missionsstrasse 64, 4055 Basel, Switzerland
*
Author to whom correspondence should be addressed.
Both are last authors.
Int. J. Mol. Sci. 2020, 21(11), 3743; https://doi.org/10.3390/ijms21113743
Received: 30 April 2020 / Revised: 21 May 2020 / Accepted: 22 May 2020 / Published: 26 May 2020
(This article belongs to the Collection Feature Papers in Molecular Genetics and Genomics)
Oxidative stress reflects a disturbance in the balance between the production and accumulation of reactive oxygen species (ROS). ROS are scavenged by the antioxidant system, but when in excess concentration, they can oxidize proteins, lipids, and DNA. DNA damage is usually repaired, and the oxidized products are excreted in urine. 8-hydroxy-2-deoxyguanosine is considered a biomarker for oxidative damage of DNA. It is needed to define background ranges for 8-OHdG, to use it as a measure of oxidative stress overproduction. We established a standardized protocol for a systematic review and meta-analysis to assess background ranges for urinary 8-OHdG concentrations in healthy populations. We computed geometric mean (GM) and geometric standard deviations (GSD) as the basis for the meta-analysis. We retrieved an initial 1246 articles, included 84 articles, and identified 128 study subgroups. We stratified the subgroups by body mass index, gender, and smoking status reported. The pooled GM value for urinary 8-OHdG concentrations in healthy adults with a mean body mass index (BMI) ≤ 25 measured using chemical methods was 3.9 ng/mg creatinine (interquartile range (IQR): 3 to 5.5 ng/mg creatinine). A significant positive association was observed between smoking and urinary 8-OHdG concentrations when measured by chemical analysis. No gender effect was observed. View Full-Text
Keywords: oxidative stress; biomarker; 8-OHdG; systematic review; meta-analysis oxidative stress; biomarker; 8-OHdG; systematic review; meta-analysis
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MDPI and ACS Style

Graille, M.; Wild, P.; Sauvain, J.-J.; Hemmendinger, M.; Guseva Canu, I.; Hopf, N.B. Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis. Int. J. Mol. Sci. 2020, 21, 3743. https://doi.org/10.3390/ijms21113743

AMA Style

Graille M, Wild P, Sauvain J-J, Hemmendinger M, Guseva Canu I, Hopf NB. Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis. International Journal of Molecular Sciences. 2020; 21(11):3743. https://doi.org/10.3390/ijms21113743

Chicago/Turabian Style

Graille, Melanie, Pascal Wild, Jean-Jacques Sauvain, Maud Hemmendinger, Irina Guseva Canu, and Nancy B. Hopf 2020. "Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis" International Journal of Molecular Sciences 21, no. 11: 3743. https://doi.org/10.3390/ijms21113743

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