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Cardiac Protective Role of Heat Shock Protein 27 in the Stress Induced by Drugs of Abuse

Department of Pharmacology, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3623;
Received: 10 March 2020 / Revised: 16 May 2020 / Accepted: 19 May 2020 / Published: 21 May 2020
Heat shock proteins (HSP) are induced after different stress situations. Some of these proteins, particularly HSP-27, function as markers to indicate cellular stress or damage and protect the heart during addictive processes. Morphine withdrawal induces an enhancement of sympathetic activity in parallel with an increased HSP-27 expression and phosphorylation, indicating a severe situation of stress. HSP-27 can interact with different intracellular signaling pathways. Propranolol and SL-327 were able to antagonize the activation of hypothalamic-pituitary adrenal (HPA) axis and the phosphorylation of HSP-27 observed during morphine withdrawal. Therefore, β-adrenergic receptors and the extracellular signal-regulated kinase (ERK) pathway would be involved in HPA axis activity, and consequently, in HSP-27 activation. Finally, selective blockade of corticotrophin releasing factor (CRF)-1 receptor and the genetic deletion of CRF1 receptors antagonize cardiac adaptive changes. These changes are increased noradrenaline (NA) turnover, HPA axis activation and decreased HSP-27 expression and phosphorylation. This suggests a link between the HPA axis and HSP-27. On the other hand, morphine withdrawal increases µ-calpain expression, which in turn degrades cardiac troponin T (cTnT). This fact, together with a co-localization between cTnT and HSP-27, suggests that this chaperone avoids the degradation of cTnT by µ-calpain, correcting the cardiac contractility abnormalities observed during addictive processes. The aim of our research is to review the possible role of HSP-27 in the cardiac changes observed during morphine withdrawal and to understand the mechanisms implicated in its cardiac protective functions. View Full-Text
Keywords: heat shock protein 27; morphine withdrawal; stress; heart heat shock protein 27; morphine withdrawal; stress; heart
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Martínez-Laorden, E.; Navarro-Zaragoza, J.; Milanés, M.V.; Laorden, M.L.; Almela, P. Cardiac Protective Role of Heat Shock Protein 27 in the Stress Induced by Drugs of Abuse. Int. J. Mol. Sci. 2020, 21, 3623.

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