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Open AccessArticle

Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in Drosophila Intestinal Stem Cells

1
Korea Nanobiotechnology Center, Pusan National University, Busan 46241, Korea
2
Department of Molecular Biology, Pusan National University, Busan 46241, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3497; https://doi.org/10.3390/ijms21103497
Received: 6 April 2020 / Revised: 1 May 2020 / Accepted: 11 May 2020 / Published: 15 May 2020
(This article belongs to the Special Issue Role of Drosophila in Human Disease Research)
Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging as an important molecule for exhibiting the anti-aging effects of caloric restriction and fasting, which are generally considered to be beneficial for stem cell maintenance and tissue regeneration. The effects of β-hydroxybutyrate on adult stem cells remain largely unknown. Therefore, this study was undertaken to investigate whether β-hydroxybutyrate supplementation exerts beneficial effects on age-related changes in intestinal stem cells that were derived from the Drosophila midgut. Our results indicate that β-hydroxybutyrate inhibits age- and oxidative stress-induced changes in midgut intestinal stem cells, including centrosome amplification (a hallmark of cancers), hyperproliferation, and DNA damage accumulation. Additionally, β-hydroxybutyrate inhibits age- and oxidative stress-induced heterochromatin instability in enterocytes, an intestinal stem cells niche cells. Our results suggest that β-hydroxybutyrate exerts both intrinsic as well as extrinsic influence in order to maintain stem cell homeostasis. View Full-Text
Keywords: Drosophila midgut; β-hydroxybutyrate; intestinal stem cell; centrosome amplification; Niche; DNA damage; heterochromatin stability; aging Drosophila midgut; β-hydroxybutyrate; intestinal stem cell; centrosome amplification; Niche; DNA damage; heterochromatin stability; aging
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Park, J.-S.; Kim, Y.-J. Anti-Aging Effect of the Ketone Metabolite β-Hydroxybutyrate in Drosophila Intestinal Stem Cells. Int. J. Mol. Sci. 2020, 21, 3497.

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