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Open AccessArticle

Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes

1
Faculté de Médecine, Biopôle de l’Université de Lorraine, Campus Brabois-Santé, Laboratoire UMR 7365 CNRS-Université de Lorraine, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, France
2
Laboratoire d’ingénierie des Biomolécules, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, France
3
Campus Brabois-Santé, Laboratoire de Travaux Pratiques de Physiologie, Faculté de pharmacie, Université de Lorraine, F-54505 Vandœuvre-Lès-Nancy, France
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(10), 3436; https://doi.org/10.3390/ijms21103436
Received: 17 April 2020 / Revised: 5 May 2020 / Accepted: 11 May 2020 / Published: 13 May 2020
(This article belongs to the Special Issue Nanomaterials for Tissue Engineering Applications)
Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due to their lipid bilayer structure similar to a biological membrane. Here we used natural rapeseed lecithin, which contains a high level of mono- and poly-unsaturated fatty acids, to evaluate the cytocompatibility of these phospholipids as future potential carriers of biomolecules in joint regenerative medicine. Results show that appropriate concentrations of nanoliposome rapeseed lecithin under 500 µg/mL were safe for chondrocytes and did not induce any alterations of their phenotype. Altogether, these results sustain that they could represent a novel natural carrier to deliver active substances into cartilage cells. View Full-Text
Keywords: liposomes; chondrocyte; PUFA; drug delivery system; joint regenerative medicine liposomes; chondrocyte; PUFA; drug delivery system; joint regenerative medicine
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MDPI and ACS Style

Bianchi, A.; Velot, É.; Kempf, H.; Elkhoury, K.; Sanchez-Gonzalez, L.; Linder, M.; Kahn, C.; Arab-Tehrany, E. Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes. Int. J. Mol. Sci. 2020, 21, 3436. https://doi.org/10.3390/ijms21103436

AMA Style

Bianchi A, Velot É, Kempf H, Elkhoury K, Sanchez-Gonzalez L, Linder M, Kahn C, Arab-Tehrany E. Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes. International Journal of Molecular Sciences. 2020; 21(10):3436. https://doi.org/10.3390/ijms21103436

Chicago/Turabian Style

Bianchi, Arnaud; Velot, Émilie; Kempf, Hervé; Elkhoury, Kamil; Sanchez-Gonzalez, Laura; Linder, Michel; Kahn, Cyril; Arab-Tehrany, Elmira. 2020. "Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes" Int. J. Mol. Sci. 21, no. 10: 3436. https://doi.org/10.3390/ijms21103436

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