Next Article in Journal
Glucocorticoids Equally Stimulate Epithelial Na+ Transport in Male and Female Fetal Alveolar Cells
Next Article in Special Issue
Does Neuraxial Anesthesia as General Anesthesia Damage DNA? A Pilot Study in Patients Undergoing Orthopedic Traumatological Surgery
Previous Article in Journal
Comparative Analysis and Expression Patterns of the PLP_deC Genes in Dendrobium officinale
Previous Article in Special Issue
DNA Oxidation and Excision Repair Pathways
Open AccessReview

DNA Damage Response and Oxidative Stress in Systemic Autoimmunity

1
First Department of Propaedeutic Internal Medicine and Joint Rheumatology Program, National and Kapodistrian University of Athens Medical School, 115 27 Athens, Greece
2
Institute of Chemical Biology, National Hellenic Research Foundation, 116 35 Athens, Greece
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(1), 55; https://doi.org/10.3390/ijms21010055
Received: 13 November 2019 / Revised: 15 December 2019 / Accepted: 18 December 2019 / Published: 20 December 2019
The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or exogenous threats, act synergistically to enhance cellular defense. On the other hand, a deregulated interplay between these systems underlines inflammatory diseases including malignancies and chronic systemic autoimmune diseases, such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Patients with these diseases are characterized by aberrant immune response to self-antigens with widespread production of autoantibodies and multiple-tissue injury, as well as by the presence of increased oxidative stress. Recent data demonstrate accumulation of endogenous DNA damage in peripheral blood mononuclear cells from these patients, which is related to (a) augmented DNA damage formation, at least partly due to the induction of oxidative stress, and (b) epigenetically regulated functional abnormalities of fundamental DNA repair mechanisms. Because endogenous DNA damage accumulation has serious consequences for cellular health, including genomic instability and enhancement of an aberrant immune response, these results can be exploited for understanding pathogenesis and progression of systemic autoimmune diseases, as well as for the development of new treatments. View Full-Text
Keywords: DNA damage response and repair network; immune response; autoimmunity; systemic lupus erythematosus; systemic sclerosis; rheumatoid arthritis; oxidative stress; abasic sites; chromatin organization; apoptosis DNA damage response and repair network; immune response; autoimmunity; systemic lupus erythematosus; systemic sclerosis; rheumatoid arthritis; oxidative stress; abasic sites; chromatin organization; apoptosis
Show Figures

Figure 1

MDPI and ACS Style

Souliotis, V.L.; Vlachogiannis, N.I.; Pappa, M.; Argyriou, A.; Ntouros, P.A.; Sfikakis, P.P. DNA Damage Response and Oxidative Stress in Systemic Autoimmunity. Int. J. Mol. Sci. 2020, 21, 55.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop