How to Make Anticancer Drugs Cross the Blood–Brain Barrier to Treat Brain Metastases
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Institut National de la Santé Et de la Recherche Médicale (INSERM), U942, 9 Rue de Chablis, 93000 Bobigny, France
2
Assistance Publique Hôpitaux de Paris, Avicenne Hospital, Department of medical oncology, 93000 Bobigny, France
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Medical Oncology Department A, National Cancer Hospital, Ha Noi 110000, Viet Nam
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AP-HP Saint-Louis Hospital, Laboratory of Pathology, 75010 Paris, France
5
Paris Diderot University/ Université Sorbonne Paris Cité, 5 rue Thomas Mann, 75013 Paris, France
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INSERM, U1165, 1 Avenue Claude Vellefaux, 75010 Paris, France
7
Paris 13 University, 99 Avenue Jean Baptiste Clément, 93430 Villetaneuse, France
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(1), 22; https://doi.org/10.3390/ijms21010022
Received: 23 November 2019 / Revised: 10 December 2019 / Accepted: 16 December 2019 / Published: 18 December 2019
(This article belongs to the Special Issue Molecular Biology of Brain Tumors)
The incidence of brain metastases has increased in the last 10 years. However, the survival of patients with brain metastases remains poor and challenging in daily practice in medical oncology. One of the mechanisms suggested for the persistence of a high incidence of brain metastases is the failure to cross the blood–brain barrier of most chemotherapeutic agents, including the more recent targeted therapies. Therefore, new pharmacological approaches are needed to optimize the efficacy of anticancer drug protocols. In this article, we present recent findings in molecular data on brain metastases. We then discuss published data from pharmacological studies on the crossing of the blood–brain barrier by anticancer agents. We go on to discuss future developments to facilitate drug penetration across the blood–brain barrier for the treatment of brain metastases among cancer patients, using physical methods or physiological transporters.
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Keywords:
brain metastases; blood–brain barrier; blood–tumor barrier; copy number profiling; mutation; anticancer drugs; pharmacokinetics
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MDPI and ACS Style
Angeli, E.; Nguyen, T.T.; Janin, A.; Bousquet, G. How to Make Anticancer Drugs Cross the Blood–Brain Barrier to Treat Brain Metastases. Int. J. Mol. Sci. 2020, 21, 22. https://doi.org/10.3390/ijms21010022
AMA Style
Angeli E, Nguyen TT, Janin A, Bousquet G. How to Make Anticancer Drugs Cross the Blood–Brain Barrier to Treat Brain Metastases. International Journal of Molecular Sciences. 2020; 21(1):22. https://doi.org/10.3390/ijms21010022
Chicago/Turabian StyleAngeli, Eurydice; Nguyen, Thuy T.; Janin, Anne; Bousquet, Guilhem. 2020. "How to Make Anticancer Drugs Cross the Blood–Brain Barrier to Treat Brain Metastases" Int. J. Mol. Sci. 21, no. 1: 22. https://doi.org/10.3390/ijms21010022
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