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Open AccessReview

Dendritic Cell-Mediated Th2 Immunity and Immune Disorders

by 1,†, 1,2,†, 1,2 and 1,2,*
1
Science Research Center (SRC) for Immune Research on Non-Lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea
2
Department of Biological Science, Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(9), 2159; https://doi.org/10.3390/ijms20092159
Received: 30 March 2019 / Revised: 29 April 2019 / Accepted: 29 April 2019 / Published: 1 May 2019
(This article belongs to the Special Issue CAR-T Cell Therapy)
Dendritic cells (DCs) are the professional antigen-presenting cells that recognize and present antigens to naïve T cells to induce antigen-specific adaptive immunity. Among the T-cell subsets, T helper type 2 (Th2) cells produce the humoral immune responses required for protection against helminthic disease by activating B cells. DCs induce a Th2 immune response at a certain immune environment. Basophil, eosinophil, mast cells, and type 2 innate lymphoid cells also induce Th2 immunity. However, in the case of DCs, controversy remains regarding which subsets of DCs induce Th2 immunity, which genes in DCs are directly or indirectly involved in inducing Th2 immunity, and the detailed mechanisms underlying induction, regulation, or maintenance of the DC-mediated Th2 immunity against allergic environments and parasite infection. A recent study has shown that a genetic defect in DCs causes an enhanced Th2 immunity leading to severe atopic dermatitis. We summarize the Th2 immune-inducing DC subsets, the genetic and environmental factors involved in DC-mediated Th2 immunity, and current therapeutic approaches for Th2-mediated immune disorders. This review is to provide an improved understanding of DC-mediated Th2 immunity and Th1/Th2 immune balancing, leading to control over their adverse consequences. View Full-Text
Keywords: dendritic cells; Th2 immunity; genetic factors; environmental factors; Th2 disorders; therapeutic approaches dendritic cells; Th2 immunity; genetic factors; environmental factors; Th2 disorders; therapeutic approaches
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MDPI and ACS Style

Kumar, S.; Jeong, Y.; Ashraf, M.U.; Bae, Y.-S. Dendritic Cell-Mediated Th2 Immunity and Immune Disorders. Int. J. Mol. Sci. 2019, 20, 2159. https://doi.org/10.3390/ijms20092159

AMA Style

Kumar S, Jeong Y, Ashraf MU, Bae Y-S. Dendritic Cell-Mediated Th2 Immunity and Immune Disorders. International Journal of Molecular Sciences. 2019; 20(9):2159. https://doi.org/10.3390/ijms20092159

Chicago/Turabian Style

Kumar, Sunil; Jeong, Yideul; Ashraf, Muhammad U.; Bae, Yong-Soo. 2019. "Dendritic Cell-Mediated Th2 Immunity and Immune Disorders" Int. J. Mol. Sci. 20, no. 9: 2159. https://doi.org/10.3390/ijms20092159

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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