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Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

1
Department of Neurology, University Clinic Heidelberg, 69120 Heidelberg, Germany
2
Clinical Cooperation Unit (CCU) Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DFKZ), 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2146; https://doi.org/10.3390/ijms20092146
Received: 30 March 2019 / Revised: 26 April 2019 / Accepted: 27 April 2019 / Published: 30 April 2019
(This article belongs to the Special Issue Calcium-Binding Proteins and Cell Signaling)
Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes. View Full-Text
Keywords: calcium-binding protein; calbindin; calretinin; parvalbumin; neurodegeneration; vulnerability calcium-binding protein; calbindin; calretinin; parvalbumin; neurodegeneration; vulnerability
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MDPI and ACS Style

Fairless, R.; Williams, S.K.; Diem, R. Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease. Int. J. Mol. Sci. 2019, 20, 2146. https://doi.org/10.3390/ijms20092146

AMA Style

Fairless R, Williams SK, Diem R. Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease. International Journal of Molecular Sciences. 2019; 20(9):2146. https://doi.org/10.3390/ijms20092146

Chicago/Turabian Style

Fairless, Richard, Sarah K. Williams, and Ricarda Diem. 2019. "Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease" International Journal of Molecular Sciences 20, no. 9: 2146. https://doi.org/10.3390/ijms20092146

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