The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders
Abstract
:1. Introduction
1.1. Vitamin K: Basic Chemical Structure and Function
1.2. Vitamin K is Associated with Ectopic Mineralization
2. Mendelian Ectopic Mineralization Diseases and Vitamin K
2.1. Pseudoxanthoma Elasticum
2.1.1. Phenotype
2.1.2. Molecular Etiology
2.1.3. Vitamin K: Role and Therapeutic Options in PXE
2.2. PXE-Like Syndrome with Multiple Coagulation Factor Deficiency
2.2.1. Phenotype
2.2.2. Molecular Etiology
2.2.3. Role of Vitamin K in the PXE-Like Syndrome
2.3. Keutel Syndrome
2.3.1. Phenotype
2.3.2. Molecular Etiology and Role of Vitamin K
3. Acquired (Vascular) Calcification Disorders and Vitamin K
Phenotypes and Vitamin K Supplementation
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
AATD | alpha-1 antitrypsin deficiency |
AB | apoptotic body |
ABCC6 | ATP-binding cassette transporter subfamily C member 6 |
AKT | AK strain transforming |
ALK1 | activin receptor-like kinase 1 |
ALP | alkaline phosphatase |
AMP | adenosine monophosphate |
ANKH | progressive ankylosis homolog protein |
ApoE | apolipoprotein E |
ATP | adenosine triphosphate |
AXL | AXL receptor tyrosine kinase |
BMP | bone morphogenetic protein |
Ca | calcium |
Ca5(PO4)3OH | calcium hydroxyapatite |
CAD | coronary artery disease |
CKD | chronic kidney disease |
CNV | choroidal neovascularization |
COPD | chronic obstructive pulmonary disease |
CTC | connective tissue calcifying disorder |
DES | (iso)desmosine |
EC | endothelial cell |
ENPP1 | ectonucleotide pyrophosphatase-phosphodiesterase 1 |
ER | endoplasmic reticulum |
GACI | generalized arterial calcification of infancy |
GAS6 | growth arrest specific-6 |
GGCX | gamma-glutamyl carboxylase |
Gla | γ-carboxylated glutamate |
Glu | glutamate |
GRP | gla-rich protein |
HE | hematoxylin-eosin |
IHC | immunohistochemistry |
KS | Keutel syndrome |
LRP1 | lipoprotein receptor-related protein 1 |
MGP | matrix gla protein |
MRP6 | multi-drug resistance-associated protein 6 |
OC | osteocalcin |
OPN | osteopontin |
OSX | osterix |
PAD | peripheral arterial disease |
Pi | inorganic phosphate |
PIVKA-II | protein induced by vitamin K absence or antagonist-II |
PO4 | phosphate |
PPi | inorganic pyrophosphate |
PXE | pseudoxanthoma elasticum |
RUNX2 | runt-related transcription factor 2 |
SMAD | small body size mothers against decapentaplegic |
SNP | single nucleotide polymorphism |
TGF-β | transforming growth factor-β |
TLR | toll-like receptor |
VC | vascular calcification |
VEGF | vascular endothelial growth factor |
Vit K | vitamin K |
VKCFD | vitamin K-dependent coagulation factor deficiency |
VKDP | vitamin K-dependent protein |
VKORC1 | vitamin K 2,3-epoxide reductase complex subunit 1 |
VSMC | vascular smooth muscle cell |
WT | wild type |
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Nollet, L.; Van Gils, M.; Verschuere, S.; Vanakker, O. The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders. Int. J. Mol. Sci. 2019, 20, 2142. https://doi.org/10.3390/ijms20092142
Nollet L, Van Gils M, Verschuere S, Vanakker O. The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders. International Journal of Molecular Sciences. 2019; 20(9):2142. https://doi.org/10.3390/ijms20092142
Chicago/Turabian StyleNollet, Lukas, Matthias Van Gils, Shana Verschuere, and Olivier Vanakker. 2019. "The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders" International Journal of Molecular Sciences 20, no. 9: 2142. https://doi.org/10.3390/ijms20092142