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The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40126 Bologna, Italy
IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy
Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603022, Russia
Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi University Hospital, 40138 Bologna, Italy
Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Huddinge University Hospital, S-141 86 Stockholm, Sweden
Institute of Molecular Genetics (IGM)-CNR, Unit of Bologna, 40136 Bologna, Italy
Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, 40136 Bologna, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(8), 2022;
Received: 14 March 2019 / Revised: 19 April 2019 / Accepted: 23 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Nutrition, Epigenetics, and Diseases)
Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic marks associated with aging. In this review, we will assess the current advances in the relationship between caloric restriction, a proven anti-aging intervention, and epigenetic signatures of aging. We will specifically discuss the impact of caloric restriction on epigenetic regulation and how some of the favorable effects of caloric restriction on lifespan and healthspan could be mediated by epigenetic modifications. View Full-Text
Keywords: aging; nutrition; caloric restriction; epigenetic clocks aging; nutrition; caloric restriction; epigenetic clocks
MDPI and ACS Style

Gensous, N.; Franceschi, C.; Santoro, A.; Milazzo, M.; Garagnani, P.; Bacalini, M.G. The Impact of Caloric Restriction on the Epigenetic Signatures of Aging. Int. J. Mol. Sci. 2019, 20, 2022.

AMA Style

Gensous N, Franceschi C, Santoro A, Milazzo M, Garagnani P, Bacalini MG. The Impact of Caloric Restriction on the Epigenetic Signatures of Aging. International Journal of Molecular Sciences. 2019; 20(8):2022.

Chicago/Turabian Style

Gensous, Noémie, Claudio Franceschi, Aurelia Santoro, Maddalena Milazzo, Paolo Garagnani, and Maria G. Bacalini. 2019. "The Impact of Caloric Restriction on the Epigenetic Signatures of Aging" International Journal of Molecular Sciences 20, no. 8: 2022.

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