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Int. J. Mol. Sci. 2019, 20(8), 1820; https://doi.org/10.3390/ijms20081820

BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine

Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China
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Received: 14 March 2019 / Revised: 9 April 2019 / Accepted: 11 April 2019 / Published: 12 April 2019
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Abstract

Currently, brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are widely used as diagnostic biomarkers for heart failure (HF) and cardiac dysfunction in clinical medicine. They are also used as postmortem biomarkers reflecting cardiac function of the deceased before death in forensic medicine. Several previous studies have reviewed BNP and NT-proBNP in clinical medicine, however, few articles have reviewed their application in forensic medicine. The present article reviews the biological features, the research and application status, and the future research prospects of BNP and NT-proBNP in both clinical medicine and forensic medicine, thereby providing valuable assistance for clinicians and forensic pathologists. View Full-Text
Keywords: BNP; NT-proBNP; heart failure; cardiac dysfunction; forensic medicine; postmortem biochemistry BNP; NT-proBNP; heart failure; cardiac dysfunction; forensic medicine; postmortem biochemistry
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Cao, Z.; Jia, Y.; Zhu, B. BNP and NT-proBNP as Diagnostic Biomarkers for Cardiac Dysfunction in Both Clinical and Forensic Medicine. Int. J. Mol. Sci. 2019, 20, 1820.

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