Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis

Stempniewicz, Agnieszka; Ceranowicz, Piotr; Warzecha, Zygmunt

doi:10.3390/ijms20071534

Open AccessReview

Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis

by

Agnieszka Stempniewicz

,

Piotr Ceranowicz

^*

and

Zygmunt Warzecha

Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Grzegórzecka 16 St., 31-531 Krakow, Poland

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2019, 20(7), 1534; https://doi.org/10.3390/ijms20071534

Submission received: 27 February 2019 / Revised: 15 March 2019 / Accepted: 19 March 2019 / Published: 27 March 2019

(This article belongs to the Special Issue Gut Hormone: From Molecular Mechanism to Clinical Aspects)

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Abstract

Chemotherapy and/or head and neck radiotherapy are frequently associated with oral mucositis. Oral pain, odynophagia and dysphagia, opioid use, weight loss, dehydration, systemic infection, hospitalization and introduction of a feeding tube should be mentioned as the main determinated effect of oral mucositis. Oral mucositis leads to a decreased quality of life and an increase in treatment costs. Moreover, oral mucositis is a life-threatening disease. In addition to its own direct life-threatening consequences, it can also lead to a reduced survival due to the discontinuation or dose reduction of anti-neoplasm therapy. There are numerous strategies for the prevention or treatment of oral mucositis; however, their effectiveness is limited and does not correspond to expectations. This review is focused on the ghrelin and obestatin as potentially useful candidates for the prevention and treatment of chemo- or/and radiotherapy-induced oral mucositis.

Keywords: gut hormone; ghrelin; obestatin; oral mucositis; chemotheraphy; radiotherapy; cancer

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MDPI and ACS Style

Stempniewicz, A.; Ceranowicz, P.; Warzecha, Z. Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis. Int. J. Mol. Sci. 2019, 20, 1534. https://doi.org/10.3390/ijms20071534

AMA Style

Stempniewicz A, Ceranowicz P, Warzecha Z. Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis. International Journal of Molecular Sciences. 2019; 20(7):1534. https://doi.org/10.3390/ijms20071534

Chicago/Turabian Style

Stempniewicz, Agnieszka, Piotr Ceranowicz, and Zygmunt Warzecha. 2019. "Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis" International Journal of Molecular Sciences 20, no. 7: 1534. https://doi.org/10.3390/ijms20071534

APA Style

Stempniewicz, A., Ceranowicz, P., & Warzecha, Z. (2019). Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis. International Journal of Molecular Sciences, 20(7), 1534. https://doi.org/10.3390/ijms20071534

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Potential Therapeutic Effects of Gut Hormones, Ghrelin and Obestatin in Oral Mucositis

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