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Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling

Department of Chemical Engineering, University of Salamanca, 37008 Salamanca, Spain
Department of Microbiology and Genetics, University of Salamanca, 37008 Salamanca, Spain
Institute for Biomedical Research of Salamanca (IBSAL), University of Salamanca, 37007 Salamanca, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1502;
Received: 27 February 2019 / Revised: 20 March 2019 / Accepted: 22 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Surface-Functionalized Nanoparticles as Drug Carriers)
PDF [5163 KB, uploaded 26 March 2019]


An environmentally friendly technique was used to produce levan-capped silver nanoparticles of about 30 nm (with a loading of 30%) that showed bactericide effect, for E. coli and B. subtilis. That effect was mathematically studied with a dose-response model (lethal dose of 12.4 ppm and 6.8 ppm respectively). These silver nanoparticles were subsequently introduced in a gel to create a silver release system with bacteria inhibition activity. Silver release from the gel and its bactericidal activity was theoretically studied to develop a unique model that is able to predict accurately both silver release and lethal dose for any type of bacteria. This model will be useful for performing predictions for future silver in gel applications. View Full-Text
Keywords: silver; nanoparticles; levan; modelling silver; nanoparticles; levan; modelling

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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González-Garcinuño, Á.; Masa, R.; Hernández, M.; Domínguez, Á.; Tabernero, A.; del Valle, E.M. Levan-Capped Silver Nanoparticles for Bactericidal Formulations: Release and Activity Modelling. Int. J. Mol. Sci. 2019, 20, 1502.

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