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Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer
Review

Therapeutic Targeting of Collective Invasion in Ovarian Cancer

1
Hudson Institute of Medical Research, Clayton VIC 3168, Australia
2
Department of Molecular and Translational Sciences, Monash University, Clayton VIC 3800, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(6), 1466; https://doi.org/10.3390/ijms20061466
Received: 26 February 2019 / Revised: 14 March 2019 / Accepted: 15 March 2019 / Published: 22 March 2019
Ovarian cancer is the seventh most commonly diagnosed cancer amongst women and has the highest mortality rate of all gynaecological malignancies. It is a heterogeneous disease attributed to one of three cell types found within the reproductive milieu: epithelial, stromal, and germ cell. Each histotype differs in etiology, pathogenesis, molecular biology, risk factors, and prognosis. Furthermore, the origin of ovarian cancer remains unclear, with ovarian involvement secondary to the contribution of other gynaecological tissues. Despite these complexities, the disease is often treated as a single entity, resulting in minimal improvement to survival rates since the introduction of platinum-based chemotherapy over 30 years ago. Despite concerted research efforts, ovarian cancer remains one of the most difficult cancers to detect and treat, which is in part due to the unique mode of its dissemination. Ovarian cancers tend to invade locally to neighbouring tissues by direct extension from the primary tumour, and passively to pelvic and distal organs within the peritoneal fluid or ascites as multicellular spheroids. Once at their target tissue, ovarian cancers, like most epithelial cancers including colorectal, melanoma, and breast, tend to invade as a cohesive unit in a process termed collective invasion, driven by specialized cells termed “leader cells”. Emerging evidence implicates leader cells as essential drivers of collective invasion and metastasis, identifying collective invasion and leader cells as a viable target for the management of metastatic disease. However, the development of targeted therapies specifically against this process and this subset of cells is lacking. Here, we review our understanding of metastasis, collective invasion, and the role of leader cells in ovarian cancer. We will discuss emerging research into the development of novel therapies targeting collective invasion and the leader cell population. View Full-Text
Keywords: ovarian cancer; leader cells; metastasis; therapies; invasion ovarian cancer; leader cells; metastasis; therapies; invasion
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MDPI and ACS Style

Moffitt, L.; Karimnia, N.; Stephens, A.; Bilandzic, M. Therapeutic Targeting of Collective Invasion in Ovarian Cancer. Int. J. Mol. Sci. 2019, 20, 1466. https://doi.org/10.3390/ijms20061466

AMA Style

Moffitt L, Karimnia N, Stephens A, Bilandzic M. Therapeutic Targeting of Collective Invasion in Ovarian Cancer. International Journal of Molecular Sciences. 2019; 20(6):1466. https://doi.org/10.3390/ijms20061466

Chicago/Turabian Style

Moffitt, Laura, Nazanin Karimnia, Andrew Stephens, and Maree Bilandzic. 2019. "Therapeutic Targeting of Collective Invasion in Ovarian Cancer" International Journal of Molecular Sciences 20, no. 6: 1466. https://doi.org/10.3390/ijms20061466

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