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Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer

1
Department of Experimental Medicine (DIMES) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 16132 Genoa, Italy
2
Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy
3
Department of Earth Science, Environment and Life (DISTAV), University of Genoa, 16132 Genoa, Italy
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Division of Medical Oncology, Galliera Hospital, 16126 Genoa, Italy
5
Wolfson Institute of Preventive Medicine, Queen Mary University of London, London E1 4NS, UK
6
Department of Experimental Medicine (DIMES), University of Genoa, 16132 Genoa, Italy
7
A.Li.Sa., Liguria Health Authority, 16121 Genoa, Italy
*
Authors to whom correspondence should be addressed.
These authors share senior authorship.
Int. J. Mol. Sci. 2019, 20(4), 890; https://doi.org/10.3390/ijms20040890
Received: 31 January 2019 / Revised: 13 February 2019 / Accepted: 15 February 2019 / Published: 19 February 2019
The crosstalk between cancer cells and host cells is a crucial prerequisite for tumor growth and progression. The cells from both the innate and adaptive immune systems enter into a perverse relationship with tumor cells to create a tumor-promoting and immunosuppressive tumor microenvironment (TME). Epithelial ovarian cancer (EOC), the most lethal of all gynecological malignancies, is characterized by a unique TME that paves the way to the formation of metastasis and mediates therapy resistance through the deregulation of immune surveillance. A characteristic feature of the ovarian cancer TME is the ascites/peritoneal fluid, a malignancy-associated effusion occurring at more advanced stages, which enables the peritoneal dissemination of tumor cells and the formation of metastasis. The standard therapy for EOC involves a combination of debulking surgery and platinum-based chemotherapy. However, most patients experience disease recurrence. New therapeutic strategies are needed to improve the prognosis of patients with advanced EOC. Harnessing the body’s natural immune defenses against cancer in the form of immunotherapy is emerging as an innovative treatment strategy. NK cells have attracted attention as a promising cancer immunotherapeutic target due to their ability to kill malignant cells and avoid healthy cells. Here, we will discuss the recent advances in the clinical application of NK cell immunotherapy in EOC. View Full-Text
Keywords: ovarian cancer; NK cells; immunotherapy; immune checkpoint; PD-1; activating receptors; B7-H6; antitumor activity; hormone therapy; adoptive therapy ovarian cancer; NK cells; immunotherapy; immune checkpoint; PD-1; activating receptors; B7-H6; antitumor activity; hormone therapy; adoptive therapy
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MDPI and ACS Style

Greppi, M.; Tabellini, G.; Patrizi, O.; Candiani, S.; Decensi, A.; Parolini, S.; Sivori, S.; Pesce, S.; Paleari, L.; Marcenaro, E. Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer. Int. J. Mol. Sci. 2019, 20, 890. https://doi.org/10.3390/ijms20040890

AMA Style

Greppi M, Tabellini G, Patrizi O, Candiani S, Decensi A, Parolini S, Sivori S, Pesce S, Paleari L, Marcenaro E. Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer. International Journal of Molecular Sciences. 2019; 20(4):890. https://doi.org/10.3390/ijms20040890

Chicago/Turabian Style

Greppi, Marco, Giovanna Tabellini, Ornella Patrizi, Simona Candiani, Andrea Decensi, Silvia Parolini, Simona Sivori, Silvia Pesce, Laura Paleari, and Emanuela Marcenaro. 2019. "Strengthening the AntiTumor NK Cell Function for the Treatment of Ovarian Cancer" International Journal of Molecular Sciences 20, no. 4: 890. https://doi.org/10.3390/ijms20040890

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