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Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors

Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Freising, 85354, Germany
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Int. J. Mol. Sci. 2019, 20(6), 1402; https://doi.org/10.3390/ijms20061402
Received: 13 February 2019 / Revised: 8 March 2019 / Accepted: 12 March 2019 / Published: 20 March 2019
(This article belongs to the Special Issue GPCR Structure and Function in Disease)
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Abstract

G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. Approximately half of the members of the human GPCR superfamily are chemosensory receptors, including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami taste receptors (TAS1Rs). Interestingly, these chemosensory GPCRs (csGPCRs) are expressed in several tissues of the body where they are supposed to play a role in biological functions other than chemosensation. Despite their abundance and physiological/pathological relevance, the druggability of csGPCRs has been suggested but not fully characterized. Here, we aim to explore the potential of targeting csGPCRs to treat diseases by reviewing the current knowledge of csGPCRs expressed throughout the body and by analysing the chemical space and the drug-likeness of flavour molecules. View Full-Text
Keywords: smell; taste; flavour molecules; drugs; chemosensory receptors; ecnomotopic expression smell; taste; flavour molecules; drugs; chemosensory receptors; ecnomotopic expression
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Di Pizio, A.; Behrens, M.; Krautwurst, D. Beyond the Flavour: The Potential Druggability of Chemosensory G Protein-Coupled Receptors. Int. J. Mol. Sci. 2019, 20, 1402.

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