Next Article in Journal
Effective Treatment of Diabetic Cardiomyopathy and Heart Failure with Reconstituted HDL (Milano) in Mice
Next Article in Special Issue
Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions
Previous Article in Journal
Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke
Previous Article in Special Issue
Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks
Open AccessReview

Causes and Mechanisms of Hematopoietic Stem Cell Aging

by Jungwoon Lee 1,†, Suk Ran Yoon 2,3,†, Inpyo Choi 2,3,* and Haiyoung Jung 2,*
1
Environmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea
2
Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea
3
Department of Functional Genomics, University of Science and Technology (UST), 113 Gwahak-ro, Yuseong-gu, Daejeon 34113, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(6), 1272; https://doi.org/10.3390/ijms20061272
Received: 15 February 2019 / Revised: 8 March 2019 / Accepted: 9 March 2019 / Published: 13 March 2019
Many elderly people suffer from hematological diseases known to be highly age-dependent. Hematopoietic stem cells (HSCs) maintain the immune system by producing all blood cells throughout the lifetime of an organism. Recent reports have suggested that HSCs are susceptible to age-related stress and gradually lose their self-renewal and regeneration capacity with aging. HSC aging is driven by cell-intrinsic and -extrinsic factors that result in the disruption of the immune system. Thus, the study of HSC aging is important to our understanding of age-related immune diseases and can also provide potential strategies to improve quality of life in the elderly. In this review, we delineate our understanding of the phenotypes, causes, and molecular mechanisms involved in HSC aging. View Full-Text
Keywords: hematopoietic stem cell aging; rejuvenation; self-renewal; differentiation hematopoietic stem cell aging; rejuvenation; self-renewal; differentiation
Show Figures

Figure 1

MDPI and ACS Style

Lee, J.; Yoon, S.R.; Choi, I.; Jung, H. Causes and Mechanisms of Hematopoietic Stem Cell Aging. Int. J. Mol. Sci. 2019, 20, 1272.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop