Intake of Red and Processed Meat, Use of Non-Steroid Anti-Inflammatory Drugs, Genetic Variants and Risk of Colorectal Cancer: A Prospective Study of the Danish “Diet, Cancer and Health” Cohort
, Ulrich Halekoh 4, Anne Tjønneland 5, Ulla Vogel 6 and Tine Iskov Kopp 5,7Round 1
Reviewer 1 Report
The collection of such a serial data is not easy. For this reason, the paper deserves such a credit for carrying out such a study. Most of analyses are carried out in a very reasonable way. I agree with the finding of the results may be important to the disease progression.
Author Response
Dear Editor
Thank you for the opportunity to revise and resubmit our manuscript entitled " Intake of red and processed meat, use of non-steroid anti-inflammatory drugs, genetic variants and risk of colorectal cancer; a prospective study of the Danish “Diet, Cancer and Health” cohort " (ijms-452480). We appreciate comments and suggestions from the reviewers; and below, we provide our responses. All changes in the manuscript version with is made with ‘track changes’.
We were not able to include the new references into the provided manuscript. Therefore, we have uploaded 2 manuscript 1) the provided manuscript with indications of the new references, and 2) the “old” manuscripts with corrections and references. We hope that this is acceptable.
On behalf of the authors,
Vibeke Andersen
Reviewer #1: Thank you for your positive comments. We have gone through the text and corrected grammar and spelling errors.
Reviewer #2: Thank you for your positive comments and for noting the incomplete sentence.
Reviewer #3: Thank you for your positive comments. We have added a sentence to the manuscript about other cancer types that have been found to be associated to TP53 rs1042522.
Reviewer 2 Report
Very well written scientific manuscript . Proposes solid data for underlying mechanisms with genetic polymorphisms and pathogenesis of CRC. Text editing may need to be done - page 11, line 16 - incomplete sentence - no other statistically. This manuscript will be a major addition to the journal
Author Response
Dear Editor
Thank you for the opportunity to revise and resubmit our manuscript entitled " Intake of red and processed meat, use of non-steroid anti-inflammatory drugs, genetic variants and risk of colorectal cancer; a prospective study of the Danish “Diet, Cancer and Health” cohort " (ijms-452480). We appreciate comments and suggestions from the reviewers; and below, we provide our responses. All changes in the manuscript version with is made with ‘track changes’.
We were not able to include the new references into the provided manuscript. Therefore, we have uploaded 2 manuscript 1) the provided manuscript with indications of the new references, and 2) the “old” manuscripts with corrections and references. We hope that this is acceptable.
On behalf of the authors,
Vibeke Andersen
Reviewer #1: Thank you for your positive comments. We have gone through the text and corrected grammar and spelling errors.
Reviewer #2: Thank you for your positive comments and for noting the incomplete sentence.
Reviewer #3: Thank you for your positive comments. We have added a sentence to the manuscript about other cancer types that have been found to be associated to TP53 rs1042522.
Reviewer 3 Report
The study "Intake of red and processed meat, use of non-steroid anti-inflammatory drugs, genetic variants and risk of colorectal cancer; a prospective study of the Danish “Diet, Cancer and Health” cohort" is of a significant interest for public health. The strengths of the present manuscript are the large sample size, the clear presentation of limitations of the study and the possible mechanistic explanations provided in the discussions.
The discussion could be enriched by a short overarching statement about the involvement of TP53 rs1042522 in other cancer types.
Author Response
Dear Editor
Thank you for the opportunity to revise and resubmit our manuscript entitled " Intake of red and processed meat, use of non-steroid anti-inflammatory drugs, genetic variants and risk of colorectal cancer; a prospective study of the Danish “Diet, Cancer and Health” cohort " (ijms-452480). We appreciate comments and suggestions from the reviewers; and below, we provide our responses. All changes in the manuscript version with is made with ‘track changes’.
We were not able to include the new references into the provided manuscript. Therefore, we have uploaded 2 manuscript 1) the provided manuscript with indications of the new references, and 2) the “old” manuscripts with corrections and references. We hope that this is acceptable.
On behalf of the authors,
Vibeke Andersen
Reviewer #1: Thank you for your positive comments. We have gone through the text and corrected grammar and spelling errors.
Reviewer #2: Thank you for your positive comments and for noting the incomplete sentence.
Reviewer #3: Thank you for your positive comments. We have added a sentence to the manuscript about other cancer types that have been found to be associated to TP53 rs1042522.
