Next Article in Journal
Comprehensive Comparative Analysis of Cholesterol Catabolic Genes/Proteins in Mycobacterial Species
Next Article in Special Issue
Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin
Previous Article in Journal
Development of the VIGS System in the Dioecious Plant Silene latifolia
Previous Article in Special Issue
Extrinsic or Intrinsic Apoptosis by Curcumin and Light: Still a Mystery
Open AccessReview

A Review of Curcumin and Its Derivatives as Anticancer Agents

1
Department of Chemical and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK
2
School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(5), 1033; https://doi.org/10.3390/ijms20051033
Received: 6 February 2019 / Revised: 16 February 2019 / Accepted: 21 February 2019 / Published: 27 February 2019
(This article belongs to the Special Issue Curcumin in Health and Disease)
Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin, the active ingredient of the Curcuma longa plant, has received great attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In this review, a summary of the medicinal chemistry and pharmacology of curcumin and its derivatives in regard to anticancer activity, their main mechanisms of action, and cellular targets has been provided based on the literature data from the experimental and clinical evaluation of curcumin in cancer cell lines, animal models, and human subjects. In addition, the recent advances in the drug delivery systems for curcumin delivery to cancer cells have been highlighted. View Full-Text
Keywords: curcumin; anticancer; structure activity relationship; cellular pathway; mechanism of action; delivery system curcumin; anticancer; structure activity relationship; cellular pathway; mechanism of action; delivery system
Show Figures

Graphical abstract

MDPI and ACS Style

Tomeh, M.A.; Hadianamrei, R.; Zhao, X. A Review of Curcumin and Its Derivatives as Anticancer Agents. Int. J. Mol. Sci. 2019, 20, 1033. https://doi.org/10.3390/ijms20051033

AMA Style

Tomeh MA, Hadianamrei R, Zhao X. A Review of Curcumin and Its Derivatives as Anticancer Agents. International Journal of Molecular Sciences. 2019; 20(5):1033. https://doi.org/10.3390/ijms20051033

Chicago/Turabian Style

Tomeh, Mhd A.; Hadianamrei, Roja; Zhao, Xiubo. 2019. "A Review of Curcumin and Its Derivatives as Anticancer Agents" Int. J. Mol. Sci. 20, no. 5: 1033. https://doi.org/10.3390/ijms20051033

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop