Next Article in Journal
Role of PD-L1 Expression in Non-Small Cell Lung Cancer and Their Prognostic Significance according to Clinicopathological Factors and Diagnostic Markers
Previous Article in Journal
Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System
Previous Article in Special Issue
Mechanisms Underlying the Visual Benefit of Cell Transplantation for the Treatment of Retinal Degenerations
Article Menu
Issue 4 (February-2) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2019, 20(4), 823; https://doi.org/10.3390/ijms20040823

Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration

1
Institute for Regenerative Medicine, Medical research and education center, Lomonosov Moscow State University, Moscow 119192, Russia
2
Faculty of Medicine, Lomonosov Moscow State University, Moscow 119192, Russia
3
Laboratory of Molecular Endocrinology, National medical research center of cardiology, Moscow 121552, Russia
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 14 January 2019 / Revised: 3 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue Advances in Cell Transplantation 2019)
Full-Text   |   PDF [928 KB, uploaded 18 February 2019]   |  

Abstract

Regeneration is a fundamental process attributed to the functions of adult stem cells. In the last decades, delivery of suspended adult stem cells is widely adopted in regenerative medicine as a leading means of cell therapy. However, adult stem cells cannot complete the task of human body regeneration effectively by themselves as far as they need a receptive microenvironment (the niche) to engraft and perform properly. Understanding the mechanisms underlying mammalian regeneration leads us to an assumption that improved outcomes of cell therapy require a specific microenvironment that is generated in damaged areas prior to stem cell delivery. To a certain extent, it may be achieved by the delivery of mesenchymal stromal cells (MSCs), not in dispersed form, but rather in self-organized cell sheets (CS) – tissue-like structures comprised of viable cells and microenvironment components: extracellular matrix and soluble factors deposited in the matrix. In this review, we highlight the potential role of MSCs as regeneration organizers and speculate that this function emerges in CS. This concept shifts our understanding of the therapeutic mechanism underlying a widely known CS-based delivery method for regenerative medicine. View Full-Text
Keywords: stem cell; stromal cell; mesenchymal stromal cell; regeneration; cell sheet; cell delivery stem cell; stromal cell; mesenchymal stromal cell; regeneration; cell sheet; cell delivery
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Nimiritsky, P.P.; Eremichev, R.Y.; Alexandrushkina, N.A.; Efimenko, A.Y.; Tkachuk, V.A.; Makarevich, P.I. Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration. Int. J. Mol. Sci. 2019, 20, 823.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top