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Int. J. Mol. Sci. 2019, 20(4), 812; https://doi.org/10.3390/ijms20040812

Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase

1
Interdisciplinary Graduate School, NTU Institute for Health Technologies, Nanyang Technological University Singapore, 50 Nanyang Avenue, Singapore 639798, Singapore
2
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore
3
INRA UMR1331, ToxAlim, 180 Chemin de Tournefeuille, 31300 Toulouse, France
4
School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, Singapore 637551, Singapore
5
Center for Integrative Genomics, University of Lausanne, Le Génopode, CH-1015 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Received: 29 December 2018 / Revised: 10 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue Integrative Physiology of the Circadian Clock)
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Abstract

Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been proposed, in association with diet, to regulate the intestinal peripheral clock. However, the effect of gut dysbiosis on liver remains elusive, despite that germfree mice show alterations in liver metabolic functions and the hepatic daily rhythm. We analyzed whether the disruption of gut microbial populations with various antibiotics would differentially impact liver functions in mice. Our results support the notion of an impact on the hepatic biological rhythm by gram-positive bacteria. In addition, we provide evidence for differential roles of gut microbiota spectra in xenobiotic metabolism that could protect against the harmful pharmacological effects of drugs. Our results underscore a possible link between liver cell proliferation and gram-positive bacteria. View Full-Text
Keywords: circadian rhythm; liver; antibiotics; gut microbiota; gene expression circadian rhythm; liver; antibiotics; gut microbiota; gene expression
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Oh, H.Y.P.; Ellero-Simatos, S.; Manickam, R.; Tan, N.S.; Guillou, H.; Wahli, W. Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase. Int. J. Mol. Sci. 2019, 20, 812.

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