Next Article in Journal
The Circadian tau Mutation in Casein Kinase 1 Is Part of a Larger Domain That Can Be Mutated to Shorten Circadian Period
Previous Article in Journal
Biomarker Analysis of Orally Dosed, Dual Active, Matrix Metalloproteinase (MMP)-2 and MMP-9 Inhibitor, AQU-118, in the Spinal Nerve Ligation (SNL) Rat Model of Neuropathic Pain
Article Menu
Issue 4 (February-2) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2019, 20(4), 812;

Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase

Interdisciplinary Graduate School, NTU Institute for Health Technologies, Nanyang Technological University Singapore, 50 Nanyang Avenue, Singapore 639798, Singapore
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, 11 Mandalay Road, Singapore 308232, Singapore
INRA UMR1331, ToxAlim, 180 Chemin de Tournefeuille, 31300 Toulouse, France
School of Biological Sciences, Nanyang Technological University Singapore, 60 Nanyang Drive, Singapore 637551, Singapore
Center for Integrative Genomics, University of Lausanne, Le Génopode, CH-1015 Lausanne, Switzerland
Author to whom correspondence should be addressed.
Received: 29 December 2018 / Revised: 10 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
(This article belongs to the Special Issue Integrative Physiology of the Circadian Clock)
Full-Text   |   PDF [4677 KB, uploaded 15 February 2019]   |  


Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been proposed, in association with diet, to regulate the intestinal peripheral clock. However, the effect of gut dysbiosis on liver remains elusive, despite that germfree mice show alterations in liver metabolic functions and the hepatic daily rhythm. We analyzed whether the disruption of gut microbial populations with various antibiotics would differentially impact liver functions in mice. Our results support the notion of an impact on the hepatic biological rhythm by gram-positive bacteria. In addition, we provide evidence for differential roles of gut microbiota spectra in xenobiotic metabolism that could protect against the harmful pharmacological effects of drugs. Our results underscore a possible link between liver cell proliferation and gram-positive bacteria. View Full-Text
Keywords: circadian rhythm; liver; antibiotics; gut microbiota; gene expression circadian rhythm; liver; antibiotics; gut microbiota; gene expression

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Oh, H.Y.P.; Ellero-Simatos, S.; Manickam, R.; Tan, N.S.; Guillou, H.; Wahli, W. Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase. Int. J. Mol. Sci. 2019, 20, 812.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top