Next Article in Journal
Development of SNP, KASP, and SSR Markers by BSR-Seq Technology for Saturation of Genetic Linkage Map and Efficient Detection of Wheat Powdery Mildew Resistance Gene Pm61
Next Article in Special Issue
Endoplasmic Reticulum Stress and Unfolded Protein Response in Breast Cancer: The Balance between Apoptosis and Autophagy and Its Role in Drug Resistance
Previous Article in Journal
Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells
Previous Article in Special Issue
A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2/Non-Type 2 Dichotomy”
Article Menu
Issue 3 (February-1) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2019, 20(3), 749;

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

Department of Pharmacology, JSS College of Pharmacy, Ooty 643001, India
Centre for Cancer Biology, University of South Australia and SA Patholology, Adelaide 5001, Australia
Laboratory of NF-κB Signaling, Institute of Molecular and Cell Biology (IMCB), Proteos 138673, Singapore
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany
Author to whom correspondence should be addressed.
Received: 11 January 2019 / Revised: 23 January 2019 / Accepted: 29 January 2019 / Published: 11 February 2019
(This article belongs to the Special Issue Endoplasmic Reticulum Stress and Unfolded Protein Response)
Full-Text   |   PDF [785 KB, uploaded 11 February 2019]   |  


It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hypoxic. Cancer cells experiencing hypoxia undergo metabolic alterations and cytoprotective adaptive mechanisms to survive such stringent conditions. While such mechanisms provide potential therapeutic targets, the mechanisms by which hypoxia regulates adaptive responses—such as ER stress response, unfolded protein response (UPR), anti-oxidative responses, and autophagy—remain elusive. In this review, we summarize the complex interplay between hypoxia and the ER stress signaling pathways that are activated in the hypoxic microenvironment of the tumors. View Full-Text
Keywords: hypoxia; endoplasmic reticulum; UPR; cancer; HIF-1; stress-response hypoxia; endoplasmic reticulum; UPR; cancer; HIF-1; stress-response

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Chipurupalli, S.; Kannan, E.; Tergaonkar, V.; D’Andrea, R.; Robinson, N. Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer. Int. J. Mol. Sci. 2019, 20, 749.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top