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Int. J. Mol. Sci. 2019, 20(3), 739; https://doi.org/10.3390/ijms20030739

Advances in Understanding the Immunological Pathways in Psoriasis

1
Department of Dermatology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
2
Department of Dermatology, Victor Babes Hospital of Infectious Diseases, 030303 Bucharest, Romania
3
Department of Physiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
4
Department of Dermatology, Prof. N.C. Paulescu National Institute of Diabetes, Nutrition and Metabolic Diseases, 030167 Bucharest, Romania
5
Department of Microbiology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania
6
Department of Immunology, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania
7
Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania
8
Faculty of Biology, University of Bucharest, 030018 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Received: 12 January 2019 / Revised: 31 January 2019 / Accepted: 8 February 2019 / Published: 10 February 2019
(This article belongs to the Special Issue Molecular Mechanisms and Pathology of Psoriasis)
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Abstract

Psoriasis vulgaris is a chronic, immune-mediated, inflammatory, polygenic skin disorder affecting approximately 2% of the population. It has a great impact on quality of life; patients often experience depression, anxiety, stigma as well as suicidal behavior. Even though psoriasis is one of the most studied dermatological conditions, the pathogenesis of the disease is still not completely elucidated. The complex interactions between keratinocytes, dendritic cells, T-lymphocytes, neutrophils and mast cells are responsible for the histopathological changes seen in psoriasis. The pathogenic model leading to the formation of psoriatic plaques has however evolved a lot over the years. There is now enough evidence to support the role of interleukin (IL) -23, IL-17, IL-22, T helper (Th) -17 cells, Th-22 cells, T regulatory cells, transforming growth factor (TGF)-β1 and IL-10 in the pathogenesis of the disease. Moreover, several inflammatory and anti-inflammatory molecules are currently being investigated, some of them showing promising results. The aim of this paper is to look over the most recent advances in the immunological pathways involved in the pathogenesis of psoriasis vulgaris. View Full-Text
Keywords: psoriasis; inflammation; immunology; Th-17; IL-17; T regulatory cells psoriasis; inflammation; immunology; Th-17; IL-17; T regulatory cells
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Georgescu, S.-R.; Tampa, M.; Caruntu, C.; Sarbu, M.-I.; Mitran, C.-I.; Mitran, M.-I.; Matei, C.; Constantin, C.; Neagu, M. Advances in Understanding the Immunological Pathways in Psoriasis. Int. J. Mol. Sci. 2019, 20, 739.

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