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Open AccessReview

Diuretic Effects of Sodium Glucose Cotransporter 2 Inhibitors and Their Influence on the Renin-Angiotensin System

Department of Pharmacology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
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Int. J. Mol. Sci. 2019, 20(3), 629; https://doi.org/10.3390/ijms20030629
Received: 4 January 2019 / Revised: 24 January 2019 / Accepted: 29 January 2019 / Published: 1 February 2019
The renin-angiotensin system (RAS) plays an important role in regulating body fluids and blood pressure. However, inappropriate activation of the RAS contributes to the pathogenesis of cardiovascular and renal diseases. Recently, sodium glucose cotransporter 2 (SGLT2) inhibitors have been used as anti-diabetic agents. SGLT2 inhibitors induce glycosuria and improve hyperglycemia by inhibiting urinary reabsorption of glucose. However, in the early stages of treatment, these inhibitors frequently cause polyuria and natriuresis, which potentially activate the RAS. Nevertheless, the effects of SGLT2 inhibitors on RAS activity are not straightforward. Available data indicate that treatment with SGLT2 inhibitors transiently activates the systemic RAS in type 2 diabetic patients, but not the intrarenal RAS. In this review article, we summarize current evidence of the diuretic effects of SGLT2 inhibitors and their influence on RAS activity. View Full-Text
Keywords: renin-angiotensin system (RAS); sodium glucose cotransporter 2 (SGLT2) inhibitor; diuretic effect; natriuresis; type 2 diabetes renin-angiotensin system (RAS); sodium glucose cotransporter 2 (SGLT2) inhibitor; diuretic effect; natriuresis; type 2 diabetes
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MDPI and ACS Style

Ansary, T.M.; Nakano, D.; Nishiyama, A. Diuretic Effects of Sodium Glucose Cotransporter 2 Inhibitors and Their Influence on the Renin-Angiotensin System. Int. J. Mol. Sci. 2019, 20, 629.

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