Next Article in Journal
Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6′-Dithiothalidomide on Traumatic Brain Injury
Next Article in Special Issue
Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike
Previous Article in Journal
mTOR Inhibitors in Advanced Biliary Tract Cancers
Previous Article in Special Issue
Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Literature
Open AccessReview

The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer

1
Department of Internal Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, Italy
2
Department of Medical Oncology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, Italy, [email protected] (G.S.)
3
Department of Gastroenterology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(3), 501; https://doi.org/10.3390/ijms20030501
Received: 21 December 2018 / Revised: 16 January 2019 / Accepted: 21 January 2019 / Published: 24 January 2019
The gut microbiota is central to the pathogenesis of several inflammatory and autoimmune diseases. While multiple mechanisms are involved, the immune system clearly plays a special role. Indeed, the breakdown of the physiological balance in gut microbial composition leads to dysbiosis, which is then able to enhance inflammation and to influence gene expression. At the same time, there is an intense cross-talk between the microbiota and the immunological niche in the intestinal mucosa. These interactions may pave the way to the development, growth and spreading of cancer, especially in the gastro-intestinal system. Here, we review the changes in microbiota composition, how they relate to the immunological imbalance, influencing the onset of different types of cancer and the impact of these mechanisms on the efficacy of traditional and upcoming cancer treatments. View Full-Text
Keywords: gut microbiota; immunological niche; dysbiosis; cancer; immune system gut microbiota; immunological niche; dysbiosis; cancer; immune system
Show Figures

Figure 1

MDPI and ACS Style

Cianci, R.; Franza, L.; Schinzari, G.; Rossi, E.; Ianiro, G.; Tortora, G.; Gasbarrini, A.; Gambassi, G.; Cammarota, G. The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer. Int. J. Mol. Sci. 2019, 20, 501. https://doi.org/10.3390/ijms20030501

AMA Style

Cianci R, Franza L, Schinzari G, Rossi E, Ianiro G, Tortora G, Gasbarrini A, Gambassi G, Cammarota G. The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer. International Journal of Molecular Sciences. 2019; 20(3):501. https://doi.org/10.3390/ijms20030501

Chicago/Turabian Style

Cianci, Rossella; Franza, Laura; Schinzari, Giovanni; Rossi, Ernesto; Ianiro, Gianluca; Tortora, Giampaolo; Gasbarrini, Antonio; Gambassi, Giovanni; Cammarota, Giovanni. 2019. "The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer" Int. J. Mol. Sci. 20, no. 3: 501. https://doi.org/10.3390/ijms20030501

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop