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Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies—Synthesis and Applications

1
Department of Pathology, Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza 12618, Egypt
2
Department of Materials Science and Nanotechnology, Faculty of Postgraduate Studies for Advanced Sciences (PSAS), Beni-Suef University, Beni-Suef 62511, Egypt
3
Department of Biotechnology, Animal Health Research Institute (AHRI), Agricultural Research Center (ARC), Giza 12618, Egypt
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Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-39182 Kalmar, Sweden
5
Chemistry Department, College of Science and Engineering, University of Leicester, Leicester LE1 7RH, UK
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(24), 6304; https://doi.org/10.3390/ijms20246304
Received: 12 November 2019 / Revised: 4 December 2019 / Accepted: 5 December 2019 / Published: 13 December 2019
(This article belongs to the Collection Feature Papers in Molecular Biophysics)
Materials that can mimic the molecular recognition-based functions found in biology are a significant goal for science and technology. Molecular imprinting is a technology that addresses this challenge by providing polymeric materials with antibody-like recognition characteristics. Recently, significant progress has been achieved in solving many of the practical problems traditionally associated with molecularly imprinted polymers (MIPs), such as difficulties with imprinting of proteins, poor compatibility with aqueous environments, template leakage, and the presence of heterogeneous populations of binding sites in the polymers that contribute to high levels of non-specific binding. This success is closely related to the technology-driven shift in MIP research from traditional bulk polymer formats into the nanomaterial domain. The aim of this article is to throw light on recent developments in this field and to present a critical discussion of the current state of molecular imprinting and its potential in real world applications. View Full-Text
Keywords: assay; molecular imprinting; nanoMIP; protein imprinting; sensor; therapeutic agent assay; molecular imprinting; nanoMIP; protein imprinting; sensor; therapeutic agent
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MDPI and ACS Style

Refaat, D.; Aggour, M.G.; Farghali, A.A.; Mahajan, R.; Wiklander, J.G.; Nicholls, I.A.; Piletsky, S.A. Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies—Synthesis and Applications. Int. J. Mol. Sci. 2019, 20, 6304. https://doi.org/10.3390/ijms20246304

AMA Style

Refaat D, Aggour MG, Farghali AA, Mahajan R, Wiklander JG, Nicholls IA, Piletsky SA. Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies—Synthesis and Applications. International Journal of Molecular Sciences. 2019; 20(24):6304. https://doi.org/10.3390/ijms20246304

Chicago/Turabian Style

Refaat, Doaa, Mohamed G. Aggour, Ahmed A. Farghali, Rashmi Mahajan, Jesper G. Wiklander, Ian A. Nicholls, and Sergey A. Piletsky 2019. "Strategies for Molecular Imprinting and the Evolution of MIP Nanoparticles as Plastic Antibodies—Synthesis and Applications" International Journal of Molecular Sciences 20, no. 24: 6304. https://doi.org/10.3390/ijms20246304

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