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Open AccessReview

Calcium Signaling in ß-cell Physiology and Pathology: A Revisit

Division of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
Research Unit Non-Coding RNAs and Genome Editing in Cancer, Medical University of Graz, 8010 Graz, Austria
Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Neue Stiftingtalstraße 6/6, 8010 Graz, Austria
BioTechMed Graz, 8010 Graz, Austria
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(24), 6110;
Received: 12 November 2019 / Revised: 28 November 2019 / Accepted: 2 December 2019 / Published: 4 December 2019
(This article belongs to the Special Issue Calcium Signaling in Human Health and Diseases 2.0)
Pancreatic beta (β) cell dysfunction results in compromised insulin release and, thus, failed regulation of blood glucose levels. This forms the backbone of the development of diabetes mellitus (DM), a disease that affects a significant portion of the global adult population. Physiological calcium (Ca2+) signaling has been found to be vital for the proper insulin-releasing function of β-cells. Calcium dysregulation events can have a dramatic effect on the proper functioning of the pancreatic β-cells. The current review discusses the role of calcium signaling in health and disease in pancreatic β-cells and provides an in-depth look into the potential role of alterations in β-cell Ca2+ homeostasis and signaling in the development of diabetes and highlights recent work that introduced the current theories on the connection between calcium and the onset of diabetes. View Full-Text
Keywords: β-cells; Ca2+ signaling; insulin secretion; diabetes; mitochondria β-cells; Ca2+ signaling; insulin secretion; diabetes; mitochondria
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MDPI and ACS Style

Klec, C.; Ziomek, G.; Pichler, M.; Malli, R.; Graier, W.F. Calcium Signaling in ß-cell Physiology and Pathology: A Revisit. Int. J. Mol. Sci. 2019, 20, 6110.

AMA Style

Klec C, Ziomek G, Pichler M, Malli R, Graier WF. Calcium Signaling in ß-cell Physiology and Pathology: A Revisit. International Journal of Molecular Sciences. 2019; 20(24):6110.

Chicago/Turabian Style

Klec, Christiane; Ziomek, Gabriela; Pichler, Martin; Malli, Roland; Graier, Wolfgang F. 2019. "Calcium Signaling in ß-cell Physiology and Pathology: A Revisit" Int. J. Mol. Sci. 20, no. 24: 6110.

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