From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells
Abstract
:1. Introduction
2. Results
2.1. Whole-Cell Electrical Activity Modeling Respecting Local Control
2.1.1. BKCa–CaV Complex with 1:1 Stoichiometry
2.1.2. BKCa–CaV Complex with 1:n Stoichiometry
2.1.3. Concise Whole-Cell Modeling Respecting Local Control
2.2. Coupling Electrical Activity with Exocytosis
Spiking versus Bursting on Evoking Exocytosis
3. Discussion
4. Methods
4.1. Electrophysiological Model of Pituitary Cells
4.1.1. BKCa Channel Modeling
4.1.2. CaV Modeling
4.1.3. BKCa Channel Open Probability for BKCa–CaV Complex with 1:1 Stoichiometry
4.1.4. BKCa Channel Open Probability for BKCa–CaV Complex with 1:n Stoichiometry
4.2. Exocytosis Model
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Montefusco, F.; Pedersen, M.G. From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells. Int. J. Mol. Sci. 2019, 20, 6057. https://doi.org/10.3390/ijms20236057
Montefusco F, Pedersen MG. From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells. International Journal of Molecular Sciences. 2019; 20(23):6057. https://doi.org/10.3390/ijms20236057
Chicago/Turabian StyleMontefusco, Francesco, and Morten G. Pedersen. 2019. "From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells" International Journal of Molecular Sciences 20, no. 23: 6057. https://doi.org/10.3390/ijms20236057