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Molecular Characterization of XX Maleness

1
Centro de Investigaciones Endocrinológicas “Dr. César Bergadá” (CEDIE), CONICET – FEI – División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, C1425EFD Buenos Aires, Argentina
2
Departamento de Histología, Biología Celular, Embriología y Genética, Facultad de Medicina, Universidad de Buenos Aires, C1121ABG Buenos Aires, Argentina
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(23), 6089; https://doi.org/10.3390/ijms20236089
Received: 12 November 2019 / Revised: 29 November 2019 / Accepted: 29 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Molecular Aspects of Sex Development in Mammals: New Insight)
Androgens and anti-Müllerian hormone (AMH), secreted by the foetal testis, are responsible for the development of male reproductive organs and the regression of female anlagen. Virilization of the reproductive tract in association with the absence of Müllerian derivatives in the XX foetus implies the existence of testicular tissue, which can occur in the presence or absence of SRY. Recent advancement in the knowledge of the opposing gene cascades driving to the differentiation of the gonadal ridge into testes or ovaries during early foetal development has provided insight into the molecular explanation of XX maleness. View Full-Text
Keywords: testis; ovary; disorders of sex development testis; ovary; disorders of sex development
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Grinspon, R.P.; Rey, R.A. Molecular Characterization of XX Maleness. Int. J. Mol. Sci. 2019, 20, 6089.

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